Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Xenin
Price:
Purity: 95.0%
Stocking Period: 10 Day
Contact: Tom

Nanjing Peptide Biotech Ltd
China
Product Name: Xenin-25
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Taiwan Oyi peptide Co. Ltd
China
Product Name: Xenin 25 acetate salt
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Vinnie

144092-28-4

144092-28-4 structure

144092-28-4 structure

Name: Xenin 25 acetate salt
Chemical Name: Xenin-25
CAS Number: 144092-28-4
Molecular Formula: C₁₃₉H₂₂₄N₃₈O₃₂S
Molecular Weight: 2971.57000
Catalog: Peptides
Create Date: 2016-07-08 03:11:01
Modify Date: 2024-01-10 10:54:09
Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.

Name	Xenin-25
Synonyms	Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Ile-Trp-Leu-OH metkephamid METKEFAMIDE Xenin

Description	Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Peptides
In Vitro	Xenin is abundantly expressed in gastric, duodenal, and jejunal mucosa, and is found at lower levels in the pancreas. Xenin is released into the circulation postprandially and has been reported to stimulatepancreatic endocrine and exocrine secretion, inhibit gastrin secretion, and influence gastrointestinal motility. Xenin is highly homologous to neurotensin. Xenin and neurotensin are reported to have similar biological effects[1].
In Vivo	Both intracerebroventricular and intraperitoneal administration of xenin inhibit fasting-induced hyperphagia in wild-type mice in a dose-dependent manner. The intraperitoneal injection of xenin also reduces nocturnal intake in ad libitum–fed wild-type mice. The intraperitoneal injection of xenin increases Fos immunoreactivity in hypothalamic nuclei, including the paraventricular nucleus and the arcuate nucleus. Xenin reduces food intake in agouti and ob/ob mice[2]. Gastric emptying rate is reduced by about 93% in xenin-treated mice compared to saline-treated control mice. The i.p. xenin injection significantly increases Fos-immunoreactive cells in the nucleus of the solitary tract of the brainstem, but not area postrema and dorsal motor nucleus of the vagus[3].
Animal Admin	Mice: Mice (wild-type and ob/ob mice) are fasted overnight (1800–1000 h) and injected with xenin intracerebroventricularly (0.1, 1, or 5 μg) or intraperitoneally (0.5, 5, 15, or 50 μg/g body wt) at 1000 h. To compare the feeding-suppressing effect between xenin and neurotensin, equimolar amounts (16.5 nmol) of xenin (50 μg/g body wt) or neurotensin (28 μg/g body) are injected intraperitoneally after an overnight fast. Control mice receive either intracerebroventricular injection of aCSF or intraperitoneal injection of saline. Preweighed food is provided to mice immediately after the injection. Cumulative food intake is measured at time points indicated in each figure up to 24 h after injection[2].
References	[1]. Cooke JH, et al. Peripheral and central administration of xenin and neurotensin suppress food intake in rodents. Obesity (Silver Spring). 2009 Jun;17(6):1135-43. [2]. Leckstrom A, et al. Xenin, a gastrointestinal peptide, regulates feeding independent of the melanocortinsignaling pathway. Diabetes. 2009 Jan;58(1):87-94. [3]. Kim ER, et al. Xenin delays gastric emptying rate and activates the brainstem in mice. Neurosci Lett. 2010 Aug 30;481(1):59-63.

Molecular Formula	C₁₃₉H₂₂₄N₃₈O₃₂S
Molecular Weight	2971.57000
Exact Mass	2969.68000
PSA	1160.01000
LogP	7.47840
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport