83435-66-9

83435-66-9 structure

Name: Delapril
Chemical Name: 2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
CAS Number: 83435-66-9
Molecular Formula: C₂₆H₃₂N₂O₅
Molecular Weight: 452.54
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-08-31 19:41:28
Modify Date: 2024-02-01 00:57:43
Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1].

Name	2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
Synonyms	Delaket (TN) Alindapril Glycine,N-(2,3-dihydro-1H-inden-2-yl)-N-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-,(S) Glycine,N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl) DELAPRIL Delaprilum [Latin] Delapril [INN] Delaprilum

Description	Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
In Vivo	Delapril (5-20 mg/kg，饮用水喂养) 可减缓胆固醇喂养兔的动脉粥样硬化进展[2]。 Delapril (1-10 mg/kg，p.o.，每日一次，持续 5 周) 在高血压大鼠中表现出自发的抗高血压作用[3]。 Animal Model: Cholesterol-fed rabbits[2] Dosage: 5 mg/kg at D5, 10 mg/kg at D10, 20 mg/kg at D20 Administration: Fed in a fixed volume (10 ml) of drinking water Result: Decreased aortic area covered by lesions. Restored endothelium-dependent relaxation
References	[1]. Onoyama K, et al. Pharmacokinetics of a new angiotensin I converting enzyme inhibitor (delapril) in patients with deteriorated kidney function and in normal control subjects. Clin Pharmacol Ther. 1988 Mar;43(3):242-9. [2]. Hernandez A,et al. Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits. Atherosclerosis. 1998 Mar;137(1):71-6. [3]. Inada Y, et al. Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986 Sep;42(1):1-8.