Delapril

Modify Date: 2024-02-01 00:57:43

Delapril Structure
Delapril structure
Common Name Delapril
CAS Number 83435-66-9 Molecular Weight 452.54
Density 1.22g/cm3 Boiling Point 659.7ºC at 760 mmHg
Molecular Formula C26H32N2O5 Melting Point N/A
MSDS N/A Flash Point 352.7ºC

 Use of Delapril


Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1].

 Names

Name 2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid
Synonym More Synonyms

 Delapril Biological Activity

Description Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1].
Related Catalog
In Vivo Delapril (5-20 mg/kg,饮用水喂养) 可减缓胆固醇喂养兔的动脉粥样硬化进展[2]。 Delapril (1-10 mg/kg,p.o.,每日一次,持续 5 周) 在高血压大鼠中表现出自发的抗高血压作用[3]。 Animal Model: Cholesterol-fed rabbits[2] Dosage: 5 mg/kg at D5, 10 mg/kg at D10, 20 mg/kg at D20 Administration: Fed in a fixed volume (10 ml) of drinking water Result: Decreased aortic area covered by lesions. Restored endothelium-dependent relaxation
References

[1]. Onoyama K, et al. Pharmacokinetics of a new angiotensin I converting enzyme inhibitor (delapril) in patients with deteriorated kidney function and in normal control subjects. Clin Pharmacol Ther. 1988 Mar;43(3):242-9.  

[2]. Hernandez A,et al. Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits. Atherosclerosis. 1998 Mar;137(1):71-6.  

[3]. Inada Y, et al. Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986 Sep;42(1):1-8.  

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 659.7ºC at 760 mmHg
Molecular Formula C26H32N2O5
Molecular Weight 452.54
Flash Point 352.7ºC
Exact Mass 452.23100
PSA 95.94000
LogP 3.00050
Index of Refraction 1.595

 Synonyms

Delaket (TN)
Alindapril
Glycine,N-(2,3-dihydro-1H-inden-2-yl)-N-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-,(S)
Glycine,N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)
DELAPRIL
Delaprilum [Latin]
Delapril [INN]
Delaprilum