Name | 3,5-dichloro-2-[4-(3,5-dichloropyridin-2-yl)oxyphenoxy]pyridine |
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Synonyms |
2,2'-[1,4-phenylenebis(oxy)]bis(3,5-dichloropyridine)
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene tcpobop 1,4-BDPOB 2,2'-[benzene-1,4-diylbis(oxy)]bis(3,5-dichloropyridine) |
Description | TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2]. |
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Related Catalog | |
Target |
Bcl-2 |
In Vivo | TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1]. Animal Model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1] Dosage: 3 mg/kg Administration: Oral; 1, 2, 5 days Result: Increased Liver weight to body weight. |
References |
Density | 1.518g/cm3 |
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Boiling Point | 444.8ºC at 760 mmHg |
Molecular Formula | C16H8Cl4N2O2 |
Molecular Weight | 402.05900 |
Flash Point | 222.8ºC |
Exact Mass | 399.93400 |
PSA | 44.24000 |
LogP | 6.67480 |
Index of Refraction | 1.635 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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