1188407-45-5

1188407-45-5 structure

Name: BMS-764459
Chemical Name: 4-[(1S)-1-Cyclopropyl-2-methoxyethyl]-6-{[6-(difluoromethoxy)-2,5 -dimethyl-3-pyridinyl]amino}-5-oxo-4,5-dihydro-2-pyrazinecarbonit rile
CAS Number: 1188407-45-5
Molecular Formula: C₁₉H₂₁F₂N₅O₃
Molecular Weight: 405.39900
Catalog: Signaling Pathways GPCR/G Protein CRFR
Create Date: 2016-03-01 04:28:42
Modify Date: 2026-07-19 23:33:26
BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer[1][2].

Name	4-[(1S)-1-Cyclopropyl-2-methoxyethyl]-6-{[6-(difluoromethoxy)-2,5 -dimethyl-3-pyridinyl]amino}-5-oxo-4,5-dihydro-2-pyrazinecarbonit rile
Synonyms	BMS-764459 >= (HPLC) BMS 764459,BMS 2-Pyrazinecbonitrile, 4-[(1S)-1-cyclopropyl-2-Methoxyethyl]-6-[[6-(difluoroMethoxy)-2,5-diMethyl-3-pyridinyl]amino]-4,5-dihydro-5-oxo 4-[(1S)-1-cyclopropyl-2-methoxyethyl]-6-[[6-(difluoromethoxy)-2,5-dimethylpyridin-3-yl]amino]-5-oxopyrazine-2-carbonitrile

Description	BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Neurological Disease
Target	CRF1[1], CYP1A1[2]
References	[1]. David K. Leahy, et al. Development of an Efficient Synthesis of Two CRF Antagonists for the Treatment of Neurological Disorders. Org. Process Res. Dev. 2010, 14, 5, 1221-1228. [2]. Simic D, et al. MicroRNA changes associated with atypical CYP1A1 inducer BMS-764459. Toxicology. 2013 Sep 15;311(3):169-77.