943650-25-7

943650-25-7 structure

Name: A-620223
Chemical Name: butanedioic acid,2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide
CAS Number: 943650-25-7
Molecular Formula: C₂₀H₂₈N₄O₅
Molecular Weight: 404.46000
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2018-12-24 10:48:43
Modify Date: 2024-01-11 17:50:07
A-620223 (succinate) (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 (succinate) (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1].

Name	butanedioic acid,2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide

Description	A-620223 (succinate) (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 (succinate) (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Penning TD, et al. Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16(14):6965-75.

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%