A-620223

Modify Date: 2024-01-11 17:50:07

A-620223 Structure
A-620223 structure
Common Name A-620223
CAS Number 943650-25-7 Molecular Weight 404.46000
Density N/A Boiling Point N/A
Molecular Formula C20H28N4O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of A-620223


A-620223 (succinate) (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 (succinate) (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1].

 Names

Name butanedioic acid,2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide

 A-620223 Biological Activity

Description A-620223 (succinate) (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 (succinate) (ABT-472) exhibits very good potency against the PARP-1 enzyme with a Ki value of 8 nM and an EC50 value of 3 nM in whole cell assay, making it useful in cancer research[1].
Related Catalog
References

[1]. Penning TD, et al. Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16(14):6965-75.  

 Chemical & Physical Properties

Molecular Formula C20H28N4O5
Molecular Weight 404.46000
Exact Mass 404.20600
PSA 150.60000
LogP 3.00910

 Safety Information

HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%