103926-82-5

103926-82-5 structure

Name: Sepimostat dimethanesulfonate
Chemical Name: (6-methanehydrazonoylnaphthalen-2-yl) 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoate,methanesulfonic acid
CAS Number: 103926-82-5
Molecular Formula: C₂₃H₂₇N₅O₈S₂
Molecular Weight: 565.61900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2017-12-01 16:08:11
Modify Date: 2025-08-27 11:50:22
Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].

Name	(6-methanehydrazonoylnaphthalen-2-yl) 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoate,methanesulfonic acid
Synonyms	6-amidino-2-naphthyl 4-<(4,5-dihydro-1H-imidazol-2-yl)amino>benzoate methanesulfonate 6-amidino-2-naphthyl 4-(2-imidazolinyl)amino-benzoate dimethanesulfonate 6-Amidino-2-naphthyl 4-<(4,5-dihydro-1H-imidazol-2-yl)amino>benzoate dimethanesulfonate 6a-methylhexahydro-2,6-methano-2H-cyclopenta<D>furan 6'-amidino-2'-naphthyl-(4-(4,5-dihydro-1H-2-imidazolyl)amino)benzoate dimethanesulfonate

Description	Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vivo	Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1]. Animal Model: Male Sprague Dawley rats weighing 150-300 g[1]. Dosage: Intravitreal injection. Administration: 1 to 100 nmol/eye. Result: Exhibited neuroprotective effects significantly.
References	[1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409.