112018-00-5

112018-00-5 structure

Name: Tebufelone
Chemical Name: 1-(3,5-ditert-butyl-4-hydroxyphenyl)hex-5-yn-1-one
CAS Number: 112018-00-5
Molecular Formula: C₂₀H₂₈O₂
Molecular Weight: 300.43500
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-02-23 08:00:00
Modify Date: 2025-08-25 14:46:25
Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].

Name	1-(3,5-ditert-butyl-4-hydroxyphenyl)hex-5-yn-1-one
Synonyms	4-(5'-hexynoyl)-2,6-di-tert-butylphenol Tebufelone Tebufelonum [INN-Latin] 5-Hexyn-1-one,1-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl) Tebufelona Tebufelone [USAN:INN] Tebufelonum Tebufelona [INN-Spanish] 4-(5'-hexynoyl)-2,6-di-t-butylphenol

Description	Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Neurological Disease
Target	COX-2 5-LO
References	[1]. S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63. [2]. Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18(14):e202300206.