110300-77-1

110300-77-1 structure

Name: taxamairin B
Chemical Name: 1,2-dimethoxy-7,7-dimethyl-3-propan-2-yldibenzo[2,4-d:4',5'-e][7]annulene-5,8-dione
CAS Number: 110300-77-1
Molecular Formula: C₂₂H₂₄O₄
Molecular Weight: 352.42400
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2017-11-18 04:27:21
Modify Date: 2024-01-17 10:49:13
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significantprotective effects in LPS-induced acute lung injury in mice[1][2].

Name	1,2-dimethoxy-7,7-dimethyl-3-propan-2-yldibenzo[2,4-d:4',5'-e][7]annulene-5,8-dione
Synonyms	Taxamairin B 1H-Dibenzo(a,d)cycloheptene-2,10-dione,6,7-dimethoxy-1,1-dimethyl-8-(1-methylethyl)

Description	Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significantprotective effects in LPS-induced acute lung injury in mice[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Inflammation/Immunology
References	[1]. Liu M, et al. Rapid access to icetexane diterpenes: Their protective effects against lipopolysaccharides-induced acute lung injury via PI3K/AKT/NF-κB axis in macrophages. Eur J Med Chem. 2023 Nov 15;260:115769. [2]. Liang JY, et al. Two new antineoplastic diterpenes from Taxus mairei. Chem Pharm Bull (Tokyo). 1987 Jun;35(6):2613-4.

HS Code	2914509090

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%