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36839-55-1

36839-55-1 structure
36839-55-1 structure
  • Name: Iodo-PEG3-Iodide
  • Chemical Name: 1,2-Bis(2-iodoethoxy)ethane
  • CAS Number: 36839-55-1
  • Molecular Formula: C6H12I2O2
  • Molecular Weight: 369.96700
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-24 12:20:11
  • Modify Date: 2025-08-25 21:39:26
  • 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].
Name 1,2-Bis(2-iodoethoxy)ethane
Synonyms Ethylene Glycol Bis(2-iodoethyl) Ether
1,2-BIS(2-IODOETHOXY)ETHANE
MFCD00075008
Description 1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].
Related Catalog
Target

PEGs

In Vitro 1,2-Bis(2-iodoethoxy)ethane is a PROTAC linker, which refers to the PEG composition. 1,2-Bis(2-iodoethoxy)ethane can be used in the synthesis of a series of PROTACs, such as MT802 (HY-122562) and SJF620 (HY-133137). PROTAC MT802（HY-122562） has a ligand specific for BTK, and a ligand specific to a E3 ligase cereblon (CRBN) connected by polyethylene glycol (PEG) linker 1,2-Bis(2-iodoethoxy)ethane[1].
References

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
Density 2.028 g/mL at 25 °C(lit.)
Boiling Point 293.5ºC at 760 mmHg
Molecular Formula C6H12I2O2
Molecular Weight 369.96700
Flash Point >230 °F
Exact Mass 369.89300
PSA 18.46000
LogP 1.88960
Index of Refraction n20/D 1.572(lit.)
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2909199090
HS Code 2909199090
Summary 2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
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