Huangshi Healthday Pharmaceutical Technology Co., Ltd.
China
Product Name: Triethylene glycol bis(p-toluenesulfonate)
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Purity: 99.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tri(ethylene glycol) di-p-toluenesulfonate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

19249-03-7

19249-03-7 structure

Name: Triethylene glycol bis(p-toluenesulfonate)
Chemical Name: 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
CAS Number: 19249-03-7
Molecular Formula: C₂₀H₂₆O₈S₂
Molecular Weight: 458.546
Catalog: Chemical reagent Organic reagent Fatty alcohol
Create Date: 2018-08-28 22:39:06
Modify Date: 2026-07-14 18:38:37
Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
Synonyms	4-methylbenzenesulfonic acid 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl ester Trivinyl glycol Bis-Tos-PEG3 Triethyleneglycol-di-p-toluenesulphonate 2-(p-Tolylsulfonyloxy)ethoxyethoxyethyl 4-methylbenzenesulfonate Triethylene glycol ditoluenesulfonate Bis(4-methylbenzenesulfonic acid)ethylenebis(oxyethylene) ester Triethylene Glycol Bis(p-toluenesulfonate) 1,8-Bis(tosyloxy)-3,6-dioxaoctane Tos-PEG3-Tos Triethylene glycol di-p-tosylate Bis(4-methylbenzenesulfonic acid)3,6-dioxa-1,8-octanediyl ester TRIETHYLGLYCOL DI-P-TOSYLATE bis-tosylated triethyleneglycol Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate) (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) PEG3-Tos 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane 2-(2-{2-[(4-methylphenyl)sulfonyloxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfon ate 1,2-BIS(2-TOSYLOXYETHOXY)ETHANE Tos-PEG4-Tos Ethanol, 2,2'-(1,2-ethanediylbis(oxy))bis-, bis(4-methylbenzenesulfonate) 1,2-Ethanediylbis(oxy-2,1-ethanediyl) bis(4-methylbenzenesulfonate) 2,2'-(ETHYLENEDIOXY)DIETHYL DITOSYLATE TSO-PEG3-OTS ethane-1,2-diylbis(oxyethane-2,1-diyl) bis(4-methylbenzenesulfonate) 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane(PEG3-Tos) (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfote) 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl4-methylbenzenesulfonate Triethylene Glycol Di-p-tosylate (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) , Triethylene glycol bis(p-toluenesulfonate) LABOTEST-BB LT00248460 2,2'-(Ethylenedioxy)diethyl Ditosylate 1,2-BIS[2-(P-TOLUENESULFONYLOXY)ETHOXY]ETHANE 2,2μ-(Ethylenedioxy)diethyl ditosylate, Triethylene glycol ditosylate 2,2-(Ethylenedioxy)diethyl ditosylat ethanol,2,2'-[oxybis(2,1-ethanediyloxy)]bis-,bis(4-methysbenzenesulfonate) TRI(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE CAS_19-7 TsOCH2(CH2OCH2)2CH2OTs Triethylene glycol bis(p-toluenesulfonate)(HPLC) TRIETHYLENE GLYCOL DITOSYLATE Triethylene glycol ditosylate ETHANOL22OXYBIS21ETHANEDIYLOXYBISBIS4METHYLBENZENESULPHONATE Triethylene glycol di(p-toluenesulfonate) 19-7 Bis(p-toluenesulfonic acid)ethylenebisoxybisethylene ester 2-[2-(2-([(4-Methylphenyl)sulfonyl]oxy)ethoxy)ethoxy]ethyl 4-methylbenzenesulfonate Triethleneglycol ditosylate TosO-(CH2CH2O)3-Tos TRIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE) 2-(2-{2-[(4-methylbenzenesulfonyl)oxy]ethoxy}ethoxy)ethyl 4-methylbenzene-1-sulfonate Triethylene glycol di(p-toluenesulfonate) triethylene glycol bis(4-toluenesulfonate) (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate) 1,2-Bis(2-tosyloxyethoxy)ethane Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate) 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane 1,2-Bis(2-tosyloxyethoxy)ethane 2,2'-(Ethylenedioxy)diethyl Ditosylate Triethylene Glycol Di-p-tosylate MFCD00048096 1,2-Bis[2-(p-toluenesulfonyloxy)ethoxy]ethane 1,10-Ditosyl-1,4,7,10-tetraoxadecane Tos-PEG3-Tos/Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate)

Description	Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Density	1.3±0.1 g/cm3
Boiling Point	608.4±55.0 °C at 760 mmHg
Melting Point	78-82 °C(lit.)
Molecular Formula	C₂₀H₂₆O₈S₂
Molecular Weight	458.546
Flash Point	321.7±31.5 °C
Exact Mass	458.106903
PSA	121.96000
LogP	2.34
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.545

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2909309090

Precursor 2
98-59-9 112-27-6
DownStream 10
111550-48-2 31249-95-3 53408-96-1 144270-95-1
17454-53-4 36839-55-1 17455-13-9 71092-59-6
929-59-9 33100-27-5

HS Code	2909309090
Summary	2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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