19608-29-8

19608-29-8 structure

Name: CB-03-01
Chemical Name: 21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
CAS Number: 19608-29-8
Molecular Formula: C₂₄H₃₄O₅
Molecular Weight: 402.524
Catalog: Research Areas Endocrinology
Create Date: 2019-01-09 19:25:53
Modify Date: 2024-01-02 22:15:36
Cortexolone 17 alpha-propionate(CB-03-01) is a new topical and peripherally selective androgen antagonist. IC50 value:Target: Androgen ReceptorCortexolone 17 alpha-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.

Name	21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
Synonyms	cortexolone 17α-propionate [(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate Pregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)- 21-Hydroxy-3,20-dioxopregn-4-en-17-yl propionate CB-03-01 Cortexolone 17 alpha-propionate

Description	Cortexolone 17 alpha-propionate(CB-03-01) is a new topical and peripherally selective androgen antagonist. IC50 value:Target: Androgen ReceptorCortexolone 17 alpha-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.
Related Catalog	Signaling Pathways >> Others >> Androgen Receptor Research Areas >> Endocrinology
References	[1]. Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165(1):177-83. [2]. Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54(12):881-6.