CB-03-01

Modify Date: 2024-01-02 22:15:36

CB-03-01 Structure
CB-03-01 structure
 Common Name CB-03-01
CAS Number 19608-29-8 Molecular Weight 402.524
Density 1.2±0.1 g/cm3 Boiling Point 538.9±50.0 °C at 760 mmHg
Molecular Formula C24H34O5 Melting Point N/A
MSDS N/A Flash Point 179.3±23.6 °C

 Use of CB-03-01


Cortexolone 17 alpha-propionate(CB-03-01) is a new topical and peripherally selective androgen antagonist. IC50 value:Target: Androgen ReceptorCortexolone 17 alpha-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.

 Names

Name 21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione
Synonym More Synonyms

 CB-03-01 Biological Activity

Description Cortexolone 17 alpha-propionate(CB-03-01) is a new topical and peripherally selective androgen antagonist. IC50 value:Target: Androgen ReceptorCortexolone 17 alpha-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.
Related Catalog
References

[1]. Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165(1):177-83.

[2]. Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54(12):881-6.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 538.9±50.0 °C at 760 mmHg
Molecular Formula C24H34O5
Molecular Weight 402.524
Flash Point 179.3±23.6 °C
Exact Mass 402.240631
PSA 80.67000
LogP 3.76
Vapour Pressure 0.0±3.3 mmHg at 25°C
Index of Refraction 1.555

 Synonyms

cortexolone 17α-propionate
[(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
Pregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)-
21-Hydroxy-3,20-dioxopregn-4-en-17-yl propionate
CB-03-01
Cortexolone 17 alpha-propionate
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: CB-03-01
  • Price: $400.0/100mg $700.0/250mg $1200.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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CB-03-01 suppliers

Price: $119/10mM*1mLinDMSO

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Related Compounds: More...
CB-03-01
73565-87-4
[(8S,10S,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] butanoate
872623-99-9
CB-5083
1542705-92-9
CB 1655
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CB 300919
289715-28-2
CB-83
333311-00-5
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57998-96-6
cb-2959
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CB-839
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Chemsrc provides CB-03-01(CAS#:19608-29-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of CB-03-01 are included as well.>> amp version: CB-03-01

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