870773-76-5

870773-76-5 structure

Name: AC 261066
Chemical Name: 4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]-2-fluorobenzoic acid
CAS Number: 870773-76-5
Molecular Formula: C₁₇H₂₀FNO₄S
Molecular Weight: 353.40800
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2016-03-18 19:25:51
Modify Date: 2024-01-10 07:58:19
AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0[1].

Name	4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]-2-fluorobenzoic acid
Synonyms	Benzoic acid,4-[4-(2-butoxyethoxy)-5-methyl-2-thiazolyl]-2-fluoro (S)-HexylHIBO UNII-LGF3F89BZP

Description	AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR
Target	RARβ2:8.0 (pEC50)
In Vitro	AC-261066 exhibits good oral bioavailability in rats (F oral = 52%)[1].
References	[1]. Lund BW, et al. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9.