AC 261066

Modify Date: 2024-01-10 07:58:19

AC 261066 Structure
AC 261066 structure
Common Name AC 261066
CAS Number 870773-76-5 Molecular Weight 353.40800
Density N/A Boiling Point N/A
Molecular Formula C17H20FNO4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AC 261066


AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0[1].

 Names

Name 4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]-2-fluorobenzoic acid
Synonym More Synonyms

 AC 261066 Biological Activity

Description AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0[1].
Related Catalog
Target

RARβ2:8.0 (pEC50)

In Vitro AC-261066 exhibits good oral bioavailability in rats (F oral = 52%)[1].
References

[1]. Lund BW, et al. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9.

 Chemical & Physical Properties

Molecular Formula C17H20FNO4S
Molecular Weight 353.40800
Exact Mass 353.11000
PSA 96.89000
LogP 4.15130

 Synonyms

Benzoic acid,4-[4-(2-butoxyethoxy)-5-methyl-2-thiazolyl]-2-fluoro
(S)-HexylHIBO
UNII-LGF3F89BZP
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