80366-85-4

• 常用中文名：Boc-NH-O-C1-NHS ester
• 常用英文名：Boc-NH-O-C1-NHS ester
• CAS号：80366-85-4
• 分子式：C₁₁H₁₆N₂O₇
• 分子量：288.25400
• 相关类别： 信号通路 蛋白裂解靶向嵌合体 PROTAC Linker
• 发布时间：2017-04-18 13:28:07
• 更新时间：2026-07-01 13:14:43
• Boc-NH-O-C1-NHS ester 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。

名称

• 中文名: [(叔丁氧羰基)氨基氧]乙酸N-琥珀酰亚胺酯
• 英文名: (2,5-dioxopyrrolidin-1-yl) 2-[(2-methylpropan-2-yl)oxycarbonylamino]oxyacetate
• 中文别名: 2-[(BOC-氨基)氧基]乙酸(2,5-二氧代-1-吡咯烷基)酯; N-SUCCINIMIDYL [(TERT-BUTOXYCBONYL)AMINOOXY]ACETATE [(叔丁氧羰基)氨基氧]乙酸N-琥珀酰亚胺酯; 2,5-二氧代吡咯烷-1-基 2-(((叔丁氧基羰基)氨基)氧基)乙酸酯
• 英文别名: N-Succinimidyl [(tert-Butoxycbonyl)aminooxy]acetate; N-Bocaminooxy-aceticacid2,5-dioxo-pyrrolidin-1-ylester; Boc-Aoa-OSu; Inhibitor,PROTAC Linkers,Boc NH O C1 NHS ester,inhibit,BocNHOC1NHS ester,Boc-NH-O-C-1-NHS ester; (Boc-aminooxy)acetic Acid N-Succinimidyl Ester; N-Boc-aminooxyacetic acid N-hydroxysuccinimide ester; Boc-aminooxyacetic acid N-hydroxysuccinimide ester; Boc-AoAc-NHS; N-Bocaminooxy-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester; N-Boc-aminooxyacetic acidN-hydroxysuccinimide ester (Assay); N'-Boc-aminooxyacetyl N-hydroxysuccinimide ester; Boc-Aoa-NHS; N-Succinimidyl (Boc-aminooxy)acetate; [(tert-Butoxycbonyl)aminooxy]acetic Acid N-Succinimidyl Ester; 2-tert-butoxycarbonylaminoxy-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester; 2,5-Dioxo-1-pyrrolidinyl 2-[(Boc-amino)oxy]acetate; [2-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-2-oxoethoxy]cbaMic Acid 1,1-DiMethylethyl Ester; 2,5-Dioxopyrrolidin-1-yl 2-(((tert-butoxycbonyl)amino)oxy)acetate; (BOC-AMINOOXY)ACETIC ACID NHS ESTER; 2-[[[(1,1-DiMethylethoxy)carbonyl]amino]oxy]acetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester; t-Boc-aminooxyacetic Acid N-Hydroxysuccinimide Ester; Acetic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]oxy]-, 2,5-dioxo-1-pyrrolidinyl ester; tBoc-aminooxyacetyl N-hydroxysuccinimide ester; tBoc-AO-OSu

物化性质

• 熔点: 114 °C
• 分子式: C₁₁H₁₆N₂O₇
• 分子量: 288.25400
• 精确质量: 288.09600
• PSA: 114.73000
• LogP: 0.19220
• 外观性状: 固体;White to Almost white powder to crystal
• 储存条件: -20°C;存放于惰性气体之中;避免光,湿气 (分解),加热

生物活性

• 描述: Boc-NH-O-C1-NHS ester 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker
• 靶点:

  Alkyl/ether

• 体外研究: PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
• 参考文献:

  [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

合成路线

6066-82-6 42989-85-5 ~92% 80366-85-4

文献：Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382

24424-99-5 ~% 80366-85-4

文献：Deroo, Stephanie; Defrancq, Eric; Moucheron, Cecile; Kirsch-De Mesmaeker, Andree; Dumy, Pascal Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8379 - 8382

上下游产品

上游产品  3
6066-82-6 42989-85-5 24424-99-5
下游产品  1
879898-82-5