42155-08-8

42155-08-8 structure

Name: Disodium 2'-deoxy-5'-O-phosphonatouridine
Chemical Name: 2′-Deoxyuridine 5′-mono-phos-phate disodium salt
CAS Number: 42155-08-8
Molecular Formula: C₉H₁₁N₂Na₂O₈P
Molecular Weight: 352.146
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Urinary (urea)pyrimidine
Create Date: 2019-01-30 13:46:38
Modify Date: 2024-01-02 14:59:16
2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].

Name	2′-Deoxyuridine 5′-mono-phos-phate disodium salt
Synonyms	5'-Uridylic acid, 2'-deoxy-, sodium salt (1:2) 2'-Deoxyuridine 5'-monophosphate disodium salt EINECS 255-687-1 Disodium 2'-deoxy-5'-O-phosphonatouridine MFCD00065282 2'-Deoxyuridine 5'-mono-phos-phate disodium salt

Description	2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn,Xi
Risk Phrases	R22
Safety Phrases	26-36-37/39
RIDADR	NONH for all modes of transport
WGK Germany	3