680611-86-3

680611-86-3 structure

Name: SGA360
Chemical Name: 3-(2,4-dimethoxyphenyl)-1-prop-2-enyl-7-(trifluoromethyl)indazole
CAS Number: 680611-86-3
Molecular Formula: C₁₉H₁₇F₃N₂O₂
Molecular Weight: 362.34600
Create Date: 2016-04-30 08:04:20
Modify Date: 2026-07-05 11:28:36
SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist)[1].

Name	3-(2,4-dimethoxyphenyl)-1-prop-2-enyl-7-(trifluoromethyl)indazole
Synonyms	3-(2,4-dimethoxyphenyl)-1-(prop-2-en-1-yl)-7-(trifluoromethyl)-1H-indazole 1H-Indazole, 3-(2,4-dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl) inhibit,Inhibitor,SGA360,SGA 360,SGA-360 SGA360, 10 mM in DMSO 1-allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole 1H-Indazole, 3-(2,4-dimethoxyphenyl)-1-(2-propenyl)-7-(trifluoromethyl)

Description	SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	SGA360 exhibits anti-inflammatory activity in vivo.
References	[1]. Iain A Murray, et al. Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol. 2010 May 17;23(5):955-66.

680611-18-1

106-95-6

680611-86-3

Literature: WYETH Patent: WO2005/39582 A1, 2005 ; Location in patent: Page/Page column 36-38 ; WO 2005/039582 A1

106-95-6

~63%

680611-86-3

680612-08-2

Literature: Wyeth Patent: US2006/111574 A1, 2006 ; Location in patent: Page/Page column 5; 6 ;

680611-18-1

106-95-6

~40%

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680612-08-2

115029-22-6

680611-86-3

680612-08-2

680610-69-9

680611-86-3

680612-08-2

138109-49-6

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680612-08-2

680610-54-2

680611-86-3

680612-08-2