SGA360

Modify Date: 2024-01-21 18:23:56

SGA360 Structure
SGA360 structure
 Common Name SGA360
CAS Number 680611-86-3 Molecular Weight 362.34600
Density N/A Boiling Point N/A
Molecular Formula C19H17F3N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SGA360


SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist)[1].

 Names

Name 3-(2,4-dimethoxyphenyl)-1-prop-2-enyl-7-(trifluoromethyl)indazole
Synonym More Synonyms

 SGA360 Biological Activity

Description SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist)[1].
Related Catalog
In Vivo SGA360 exhibits anti-inflammatory activity in vivo.
References

[1]. Iain A Murray, et al. Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol. 2010 May 17;23(5):955-66.

 Chemical & Physical Properties

Molecular Formula C19H17F3N2O2
Molecular Weight 362.34600
Exact Mass 362.12400
PSA 36.28000
LogP 4.92530

 Synthetic Route

3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole structure

3-(2,4-dimethox...

CAS#:680611-18-1

allyl bromide structure

allyl bromide

CAS#:106-95-6

~%

SGA360 Structure

SGA360

CAS#:680611-86-3

Literature: WYETH Patent: WO2005/39582 A1, 2005 ; Location in patent: Page/Page column 36-38 ; WO 2005/039582 A1
allyl bromide structure

allyl bromide

CAS#:106-95-6

~63%

SGA360 Structure

SGA360

CAS#:680611-86-3

2-allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-2H-indazole structure

2-allyl-3-(2,4-...

CAS#:680612-08-2

Literature: Wyeth Patent: US2006/111574 A1, 2006 ; Location in patent: Page/Page column 5; 6 ;
3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole structure

3-(2,4-dimethox...

CAS#:680611-18-1

allyl bromide structure

allyl bromide

CAS#:106-95-6

~40%

SGA360 Structure

SGA360

CAS#:680611-86-3

2-allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-2H-indazole structure

2-allyl-3-(2,4-...

CAS#:680612-08-2

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
2-Fluoro-3-(trifluoromethyl)benzoic acid structure

2-Fluoro-3-(tri...

CAS#:115029-22-6

~%

SGA360 Structure

SGA360

CAS#:680611-86-3

2-allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-2H-indazole structure

2-allyl-3-(2,4-...

CAS#:680612-08-2

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
(2,4-dimethoxyphenyl)-[2-fluoro-3-(trifluoromethyl)phenyl]methanone structure

(2,4-dimethoxyp...

CAS#:680610-69-9

~%

SGA360 Structure

SGA360

CAS#:680611-86-3

2-allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-2H-indazole structure

2-allyl-3-(2,4-...

CAS#:680612-08-2

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
2,4-dimethoxyphenylmagnesium bromide structure

2,4-dimethoxyph...

CAS#:138109-49-6

~%

SGA360 Structure

SGA360

CAS#:680611-86-3

2-allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-2H-indazole structure

2-allyl-3-(2,4-...

CAS#:680612-08-2

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966
2-fluoro-N-methoxy-N-methyl-3-(trifluoromethyl)benzamide structure

2-fluoro-N-meth...

CAS#:680610-54-2

~%

SGA360 Structure

SGA360

CAS#:680611-86-3

2-allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-2H-indazole structure

2-allyl-3-(2,4-...

CAS#:680612-08-2

Literature: Murray, Iain A.; Krishnegowda, Gowdahalli; Dinatale, Brett C.; Flaveny, Colin; Chiaro, Chris; Lin, Jyh-Ming; Sharma, Arun K.; Amin, Shantu; Perdew, Gary H. Chemical Research in Toxicology, 2010 , vol. 23, # 5 p. 955 - 966

 Synonyms

SGA360
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Chemsrc provides SGA360(CAS#:680611-86-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SGA360 are included as well.>> amp version: SGA360

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