306301-68-8

306301-68-8 structure

306301-68-8 structure

Name: SKI-I
Chemical Name: ski-i
CAS Number: 306301-68-8
Molecular Formula: C₂₅H₁₈N₄O₂
Molecular Weight: 406.43600
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-12-13 02:29:15
Modify Date: 2024-01-10 13:02:28
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2].

Name	ski-i
Synonyms	Sphingosine Kinase Inhibitor, SKI-I 5-naphthalen-2-yl-1H-pyrazol-3-carboxylic acid (2-hydroxynaphthalen-1-ylmethylene)-hydrazide

Description	SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> SPHK
Target	IC50: 1.2 μM (ST-hSK); 11 μM (hERK2)[1]
In Vitro	SKI-I (Compound I; 5 μg/mL) inhibits SK activity by 99%[1]. SKI-I (10 μM; 24 h) induces the apoptosis of T24 cells[1].
References	[1]. French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9. [2]. Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep;45(9):4149-56.

Molecular Formula	C₂₅H₁₈N₄O₂
Molecular Weight	406.43600
Exact Mass	406.14300
PSA	90.37000
LogP	5.24350

Hazard Codes	Xi