66-97-7

66-97-7 structure

Name: Psoralen
Chemical Name: psoralen
CAS Number: 66-97-7
Molecular Formula: C₁₁H₆O₃
Molecular Weight: 186.163
Catalog: API Special medicine Dermatology medication
Create Date: 2018-02-04 08:00:00
Modify Date: 2026-07-12 20:41:53
Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3].

Name	psoralen
Synonyms	Furo[2',3':7,6]coumin Psoralen, froM Psoralea corylifolia L Furo[2'.3':7.6]coumin Fructus Psoraleae extract 7H-Furo[3,2-γ],benzopyran-7-one 7-furo[3,2-g]benzopyranone Psoralen, >= 5-Benzofuranacrylic acid, 6-hydroxy-, delta-lactone 7H-Furo[3,2-g]chromen-7-one prosuler Psoralea extract EINECS 200-639-7 Psoralene in stock Psoralen -7 7H-Furo[3,2-g]benzopyran-7-one, Furo[3,2-g]coumin 6,7-Furanocoumin Furo(4',5',6,7)coumin Extract psoralen extract Furocoumin FURO[3,2-G]COUMIN Furocoumarin Psoralen,7H-Furo[3,2-g]benzopyran-7-one, Furo[3,2-g]coumin Psoralen (Ficusin) 6-hydroxy-5-benzofuranacrylicacidelta-lactone 6-Hydroxy-5-benzofuranacrylic acid γ-lactone Furo[4’,5’:6,7]coumin Furo[3,2-g]chromen-7-one 7H-Furo[3,2-g][1]benzopyran-7-one Furo[4',5':6,7]coumin PSORALEAE FRUCTUS 7h-furo[3,2-g]benzopyran-7-one Psoralen> Psoralea corylifolia Linn. Extract MFCD00010520 PSORALEN 3-(6-hydroxy-5-benzofuranyl)-2-propenoicacidelta-lactone TRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRRY MJJNNNNNNN furo(2’,3’,7,6)coumin Prosuler FURO[3,2-G]BENZOPYRAN-7-ONE Psoralen //BP Furo[3,2-γ],coumin PSORALEN hplc Psorline-P Psoralen (psoralene, Ficusin, Furocoumin) PSORALEN(SH) 3-(6-Hydroxy-5-benzofuranyl)-2-propenoic Acid δ-Lactone Psoralen from Psoralea corylifolia L 6,7-Furanocoumarin 2-Propenoicacid,3-(6-hydroxy-5-benzofuranyl)-,δ-lactone Furo(2',3',7,6)coumin furo(4’,5’,6,7)coumin 2-Propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, delta-lactone PSORALEN, FOR FLUORESCENCE furo(2’,3’:7’,6)coumin furo[3,2-g]chromen-2-one Furo[2’,3’:7,6]coumin FICUSIN 6-hydroxy-5-benzofuranacrylicacidbeta-lactone furo(4’,5’:6,7)coumin

Description	Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.IC50 value:Target:in vitro: Psoralen dosages of 1-10 μM exhibited low cytotoxicity toward chondrocytes. However, a dosage of 100 μM suppressed the proliferation of chondrocytes. Different concentrations of psoralen treatments on chondrocytes revealed that GAG and Type II collagen synthesis increased, especially at 100 μM, by 0.39-fold and 0.48-fold, respectively, on day 3, and by 0.51-fold and 0.56-fold, respectively, on day 9 [1]. in vivo: Tumor volume inhibition rates were 43.75% and 40.18%, respectively, in the psoralen and isopsoralen low-dose groups, and tumor weight inhibition rates were 38.83% and 37.77%. Tumor volume inhibition rates were 67.86% and 66.96%, respectively, in the psoralen and isopsoralen high-dose groups, and tumor weight inhibition rates were 49.47% and 47.87% [2]. psoralen can inhibit metastasis of breast cancer to bone in vivo. Histological, molecular biological, and imaging analyses revealed that psoralen inhibits bone metastases in mice [3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Phenylpropanoids
References	[1]. Xu K, et al. Psoralen activates cartilaginous cellular functions of rat chondrocytes in vitro. Pharm Biol. 2014 Dec 4:1-6. [2]. Lu H, et al. Isolation and purification of psoralen and isopsoralen and their efficacy and safety in the treatment of osteosarcoma in nude rats. Afr Health Sci. 2014 Sep;14(3):641-7. [3]. Wu C, et al. Psoralen inhibits bone metastasis of breast cancer in mice. Fitoterapia. 2013 Dec;91:205-10.

Density	1.4±0.1 g/cm3
Boiling Point	362.6±27.0 °C at 760 mmHg
Melting Point	160-162 °C
Molecular Formula	C₁₁H₆O₃
Molecular Weight	186.163
Flash Point	173.1±23.7 °C
Exact Mass	186.031693
PSA	43.35000
LogP	1.67
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.667
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV0944000

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one

CAS REGISTRY NUMBER :: 66-97-7

BEILSTEIN REFERENCE NO. :: 0152784

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C11-H6-O3

MOLECULAR WEIGHT :: 186.17

WISWESSER LINE NOTATION :: T C566 DO LVOJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 50 umol/L

REFERENCE :: BUCABS Bulletin du Cancer. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1966- Volume(issue)/page/year: 67,245,1980

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R36/37/38
Safety Phrases	S26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LV0944000

Precursor 9
849144-95-2 6544-89-4 7535-48-0 16851-02-8
52656-95-8 15085-71-9 287171-02-2 13196-11-7
623-47-2
DownStream 4
20073-22-7 6544-89-4 7535-48-0 19881-52-8

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