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128446-35-5

128446-35-5 structure
128446-35-5 structure
  • Name: Hydroxypropyl-β-cyclodextrin
  • Chemical Name: (2-Hydroxypropyl)-β-cyclodextrin
  • CAS Number: 128446-35-5
  • Molecular Formula: C63H112O42
  • Molecular Weight: 1541.538
  • Catalog: Biochemical Carbohydrate Polysaccharide
  • Create Date: 2018-08-28 19:12:09
  • Modify Date: 2026-07-01 11:25:16
  • (2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.
Name (2-Hydroxypropyl)-β-cyclodextrin
Synonyms EINECS 420-920-1
ade hydroxypropyl beta cyclodextrin
(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN
MFCD00069372
Injection ade hydroxypropyl betadex
Hydroxypropyl-beta-Cyclodextrin,Hydroxypropyl betadex
(2-HYDROXYPROPYL)-β-CYCLODEXTRIN
Hydroxypropyl Betadex
(2-Hydroxypropyl)-beta-cyclode
(2-Hydroxypropyl)-beta-cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany
(94-6) hydroxypropyl-beta-cyclodextrin
HP-β-CD, hydroxypropyl-β-cyclodextrin
(2-Hydroxypropyl)-Beta-Cyclodextrin
hydropropyl beta cyclodextrin
Hydroxypropyl betadex, 2-Hydroxypropyl-b-cyclodextrin
HYDROXYPROPYL-BETA-CYCLODEXTRIN, MS = 0. 6
Cavasol W7 HP
2-hydroxypropyl-beta-cyclodextirn
(2-Hydroxypropyl)-^b-cyclodextrin, avge. MW ca
(2-Hydroxypropyl)-β-cyclodextrin, avge. MW ca
(2-Hydroxypropyl)-beta-cyclodextrin, MW ca 10
beta-cyclodextrin,2-hydroxypropylether
HP-beta-CD
Hydroxypropyl Beta Cyclodextrin sythetic
injection hydroxypropyl-beta-cyclodextrin
HPBCD\/(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN
(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN (MS=1.0)
2-hydroxypropylether-beta-cyclodextrin
(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN，Hydroxypropyl-beta-cyclodextrin
(2-Hydroxypropyl)-^b-cyclodextrin, MW ca 10
HPBCD/HPCD
(2-Hydroxypropyl)-beta-cyclodextrin, avge. MW ca
Hydroxypropyl-beta-cyclodextrin, R
Hydroxypropyl-beta-cyclodextrin
(2-Hydroxypropyl)-Beta-Cyclodextri
beta-hydroxypropylcyclodextrin
HYDROXYPROPYL-BETA-CYCLODEXTRIN (MS = 0. 8)
2-HYDROXYPROPYL-B-CYCLODEXTRIN CELLCULTU RE TESTED
Phmaceutical ade hydroxypropyl betadex
2-Hydroxypropyl-B-Cyclodextrin
(2-Hydroxypropyl)-β-cyclodextrin (HP-β-CD)
Hydroxypropyl beta cyclodextrin aqueous solution
HYDROXYPROPYL B-CYCLODEXTRIN , NF
2-Hydroxypropyl-beta-cyclodextrin in stock Factory
CAVASOL(R)W7
Hydroxypropyl-b-cyclodextrin
Hydroxypropyl-β-cyclodextrin(HP-β-CD)
(2-Hydroxypropyl)-beta-cyclodextrin (DS~4.5)
β-Cyclodextrin 2-Hydroxypropyl Ethers
2-Hydroxypropyl-&beta
Hydroxypropylbetadex CRS
Description (2-Hydroxypropyl)-β-cyclodextrin is a widely used drug delivery vehicle to improve the stability and bioavailability.
Related Catalog
In Vitro Cell treatment with (2-Hydroxypropyl)-β-cyclodextrin results in the activation of the transcription factor EB, a master regulator of lysosomal function and autophagy, and in enhancement of the cellular autophagic clearance capacity[1]. (2-Hydroxypropyl)-β-cyclodextrin treatment reduces intracellular cholesterol resulting in significant leukemic cell growth inhibition through G2/M cell-cycle arrest and apoptosis. The IC50 values for (2-Hydroxypropyl)-β-cyclodextrin after 72 hours exposure are in the range of 3.86–10.09 mM. (2-Hydroxypropyl)-β-cyclodextrin also shows anticancer effects against CML cells expressing a T315I BCR-ABL mutation (that confers resistance to most ABL tyrosine kinase inhibitors), and hypoxia-adapted CML cells that have characteristics of leukemic stem cells. In addition, colony forming ability of human primary AML and CML cells is inhibited by (2-Hydroxypropyl)-β-cyclodextrin[2].
In Vivo (2-Hydroxypropyl)-β-cyclodextrin administration promotes transcription factor EB-mediated clearance of proteolipid aggregates that accumulate due to inefficient activity of the lysosome-autophagy system in cells derived from a patient with a lysosomal storage disorder[1]. Intraperitoneal injection of (2-Hydroxypropyl)-β-cyclodextrin significantly improves survival in leukemia mouse models. Systemic administration of (2-Hydroxypropyl)-β-cyclodextrin to mice has no significant adverse effects[2].
Cell Assay Cells are incubated with (2-Hydroxypropyl)-β-cyclodextrin at various concentrations (5, 7.5, 10, 15, 20 mM) for 72 hours. Cell viability is assessed using a trypan blue dye exclusion method and cell proliferation is evaluated using a modified methyl-thiazol-diphenyl- tetrazolium (MTT) assay[2].
Animal Admin Mice: Mice are intraperitoneally injected with 200 μL vehicle (saline) or (2-Hydroxypropyl)-β-cyclodextrin (50 or 150 mM) for 20 consecutive days 3 days after transplantation, and survival is monitored daily. Leukemic cell engraftment is confirmed by detection of GFP-positive cells in the recipient’s BM using flow cytometry[2].
References

[1]. Song W, et al. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4;289(14):10211-22.

[2]. Yokoo M, et al. 2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. PLoS One. 2015 Nov 4;10(11):e0141946.
Density 1.4±0.1 g/cm3
Boiling Point 1521.9±60.0 °C at 760 mmHg
Melting Point 278ºC (dec.)
Molecular Formula C63H112O42
Molecular Weight 1541.538
Flash Point 874.2±32.9 °C
Exact Mass 1540.662842
PSA 618.66000
LogP -6.23
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.545
Storage condition 2-8°C
Water Solubility H2O: 45 % (w/v) | Soluble in water.
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS GU2293332
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title: CAS No. 128446-35-5 | Chemsrc address: https://m.chemsrc.com/en/baike/390988.html

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