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25086-89-9

25086-89-9 structure
25086-89-9 structure
  • Name: Poly(1-vinylpyrrolidone-co-vinyl acetate)
  • Chemical Name: Poly(1-vinylpyrrolidone-co-vinyl acetate)
  • CAS Number: 25086-89-9
  • Molecular Formula: (C6H9NO.C4H6O2)n
  • Molecular Weight: 486.726
  • Catalog: Catalysts and additives polymer
  • Create Date: 2018-03-01 08:00:00
  • Modify Date: 2024-01-02 22:31:55
  • Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Name Poly(1-vinylpyrrolidone-co-vinyl acetate)
Synonyms copolyvidone
kolima35
gaf-s630
Cholest-8(14)-ene-3,6-diyl diacetate
kolima10
s630
Cholest-8(14)-ene-3,6-diol, diacetate
MFCD00134018
pvp-va
VP/VA Copolymers Powder
Description Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Related Catalog
References

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

Density 1.0±0.1 g/cm3
Boiling Point 536.7±50.0 °C at 760 mmHg
Molecular Formula (C6H9NO.C4H6O2)n
Molecular Weight 486.726
Flash Point 254.7±28.5 °C
Exact Mass 486.370911
PSA 46.61000
LogP 9.76
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.517
Stability Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AH3539000
CHEMICAL NAME :
Acetic acid, ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone
CAS REGISTRY NUMBER :
25086-89-9
LAST UPDATED :
199710
DATA ITEMS CITED :
4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>630 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),141,1983
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R10
Safety Phrases S22-S24/25
RIDADR UN 1987 3/PG 2
WGK Germany 1
RTECS AH3539000
Packaging Group II
Hazard Class 3.0

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