Poly(1-vinylpyrrolidone-co-vinyl acetate)

Modify Date: 2024-01-02 22:31:55

Poly(1-vinylpyrrolidone-co-vinyl acetate) structure	Common Name	Poly(1-vinylpyrrolidone-co-vinyl acetate)
	CAS Number	25086-89-9	Molecular Weight	486.726
	Density	1.0±0.1 g/cm3	Boiling Point	536.7±50.0 °C at 760 mmHg
	Molecular Formula	(C₆H₉NO_.C₄H₆O₂)n	Melting Point	N/A
	MSDS	USA	Flash Point	254.7±28.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of Poly(1-vinylpyrrolidone-co-vinyl acetate)

Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].

Name	Poly(1-vinylpyrrolidone-co-vinyl acetate)
Synonym	More Synonyms

Description	Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Density	1.0±0.1 g/cm3
Boiling Point	536.7±50.0 °C at 760 mmHg
Molecular Formula	(C₆H₉NO_.C₄H₆O₂)n
Molecular Weight	486.726
Flash Point	254.7±28.5 °C
Exact Mass	486.370911
PSA	46.61000
LogP	9.76
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.517
Stability	Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH3539000

CHEMICAL NAME :: Acetic acid, ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone

CAS REGISTRY NUMBER :: 25086-89-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >630 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),141,1983

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R10
Safety Phrases	S22-S24/25
RIDADR	UN 1987 3/PG 2
WGK Germany	1
RTECS	AH3539000
Packaging Group	II
Hazard Class	3.0