Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Lipoic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Alphalipoic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: (+)-Thioctic acid
Price: ￥Inquiry/25kg
Purity: 99.0%
Stocking Period: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

62-46-4

62-46-4 structure

Name: (+)-Thioctic acid
Chemical Name: lipoic acid
CAS Number: 62-46-4
Molecular Formula: C₈H₁₄O₂S₂
Molecular Weight: 206.326
Catalog: API Digestive system medication Liver disease medication
Create Date: 2018-08-12 14:35:30
Modify Date: 2026-06-29 19:21:56
>98%,Standard References

Name	lipoic acid
Synonyms	Thiooctanoicacid Thioci acid Thiocitic Acid Tioctacid D-THIOCTIC ACID THIOCITIC ACID/DL-THIOCTIC ACID alpha-Liponsaeure (German) Protogen A 1,2-Dithiolane-3-pentanoic acid 5-(1,2-Dithiolan-3-yl)valeriansure R-LIPOIC ACID POTASSIUM COMPOUND Thiotic acid (R)-(+)-lipoic acid BioaActive ALA 5-[(3R)-1,2-Dithiolan-3-yl]pentanoic acid PoassiumR-Lipoate 5-[3-(1,2-Dithiolanyl)]pentanoic Acid Thioctsan 6-Thiotic acid Thioktsaeure 6,8-Thiotic acid 6-Thioticacid Biletan Lipoicin Thioctidase Acetate-rlacingfactor 5-(dithiolan-3-yl)pentanoic acid Tioctidasi acetate rlacing factor 5-(1,2-DITHIOLAN-3-YL)VALERIC ACID/ALPHA LIPOIC ACID 5-(1,2-Dithiolan-3-yl)valerianic acid (R)-Lipoic Acid Potassium 5-(1,2-Dithiolan-3-yl)valeric acid Acetate-rlacing factor 6,8-Thioticacid Dl-Alpha-LipoicAcid (R)-α-Lipoic Acid 5-(Dihydro-3H-1,2-dithiol-3-yl)pentanoic acid 6-Thioctic acid α-Lipoic acid Lipoic acid Nanoactive ALA Pyruvate oxidation factor DL-Alpha lipoic Acid(Thioctic Acid) Tioctidasi R-Alpha-Lipoic Acid 6,8-Thioctic acid R enantiomer of alpha-lipoic acid (R)-(+)-α-Lipoic acid 6,8-Thiocticacid Nano Liposomal Alpha lipoic acid BioActive Alpha lipoic acid Lipothion Tioctan Soluble ALA Liposan Soluble alpha lipoic acid a-Liponic acid Thioctic acid MFCD01631142 Thioctic d-[3-(1,2-Dithiacyclopentyl)]pentanoic Acid EINECS 200-534-6 Hlipon δ-[3-(1,2-dithiacyclopentyl)]pentanoic acid a-Lipoic Acid Acetate Replacing Factor (+)-α-Lipoic acid alpha-Liponsaeure 5-[3-(1,2-dithiolanyl)]pentanoic acid NanoActive Alpha lipoic acid ThiocticAcid(AlphaLipoicAcid) 6-Thiocticacid Thioctan Tioctidasiacetaterlacingfactor Thioctacid Thioctic acid API Thiooctanoic acid

Density	1.2±0.1 g/cm3
Boiling Point	362.5±11.0 °C at 760 mmHg
Melting Point	48-52 °C(lit.)
Molecular Formula	C₈H₁₄O₂S₂
Molecular Weight	206.326
Flash Point	173.0±19.3 °C
Exact Mass	206.043518
PSA	87.90000
LogP	2.16
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.562

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP1190000

CHEMICAL NAME :: 1,2-Dithiolane-3-valeric acid

CAS REGISTRY NUMBER :: 62-46-4

BEILSTEIN REFERENCE NO. :: 0122410

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C8-H14-O2-S2

MOLECULAR WEIGHT :: 206.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 502 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 41,79,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,454,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 197 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 60,278,1964 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 480 mg/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 68,265,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9998 No. of Facilities: 138 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 429 (estimated) No. of Female Employees: 141 (estimated)

Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S24/25
WGK Germany	3
HS Code	2934999090

Precursor 0
DownStream 1
119365-69-4

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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