581809-67-8

581809-67-8 structure

Name: A 425619
Chemical Name: 1-isoquinolin-5-yl-3-[[4-(trifluoromethyl)phenyl]methyl]urea
CAS Number: 581809-67-8
Molecular Formula: C₁₈H₁₄F₃N₃O
Molecular Weight: 345.31800
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2017-02-07 18:12:11
Modify Date: 2024-02-06 19:49:08
A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain[1].

Name	1-isoquinolin-5-yl-3-[[4-(trifluoromethyl)phenyl]methyl]urea
Synonyms	1-(4-(trifluoromethyl)benzyl)-3-(isoquinolin-5-yl)urea

Description	A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Inflammation/Immunology
In Vivo	A-425619 (i.p., 100 μmoL/kg) 可以恢复弗氏完全佐剂（CFA；10 mg/mL）诱导的膝关节炎症引起的 C57BL/6J 小鼠自发挖掘行为的减少[1]。
References	[1]. Sampurna Chakrabarti, et al. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. Neuropharmacology. 2018 Dec;143:49-62.