A 425619

Modify Date: 2024-02-06 19:49:08

A 425619 Structure
A 425619 structure
Common Name A 425619
CAS Number 581809-67-8 Molecular Weight 345.31800
Density N/A Boiling Point N/A
Molecular Formula C18H14F3N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of A 425619


A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain[1].

 Names

Name 1-isoquinolin-5-yl-3-[[4-(trifluoromethyl)phenyl]methyl]urea
Synonym More Synonyms

 A 425619 Biological Activity

Description A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain[1].
Related Catalog
In Vivo A-425619 (i.p., 100 μmoL/kg) 可以恢复弗氏完全佐剂(CFA;10 mg/mL)诱导的膝关节炎症引起的 C57BL/6J 小鼠自发挖掘行为的减少[1]。
References

[1]. Sampurna Chakrabarti, et al. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. Neuropharmacology. 2018 Dec;143:49-62. 

 Chemical & Physical Properties

Molecular Formula C18H14F3N3O
Molecular Weight 345.31800
Exact Mass 345.10900
PSA 57.51000
LogP 4.85270

 Synonyms

1-(4-(trifluoromethyl)benzyl)-3-(isoquinolin-5-yl)urea
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