1448346-63-1
1448346-63-1 structure
- Name: AG-120
- Chemical Name: (2S)-N-(1 -(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
- CAS Number: 1448346-63-1
- Molecular Formula: C28H22ClF3N6O3
- Molecular Weight: 582.96
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Isocitrate Dehydrogenase (IDH)
- Create Date: 2017-02-23 03:30:20
- Modify Date: 2026-08-02 14:36:55
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IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer[1].
| Name | (2S)-N-(1 -(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
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| Synonyms |
AG-120 Racemate
1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide AG120/Ivosidenib-API Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl) Ivosideni, racemic mixture AG 120 (racemic),AG120 (racemic) AG-120 (racemic), 10 mM in DMSO 13C5]-Ivosideni, racemic mixture (2S)-N-(1 -(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-cboxamide 2-(2-chlorophenyl)-2-{1-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]-N-(5-fluoropyridin-3-yl)formamido}-N-(3,3-difluorocyclobutyl)acetamide AG-120 Ivosidenib (R,S)-Ivosidenib (AG-120) Ivosidenib (RG-120 racemic) RG-120(racemic) AG-120 (Ivosidenib) racemic 2-(2-chlorophenyl)-2-{1-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]-N-(5-fluoropyridin-3-yl)formamido}-N-(3,3-difluorocyclobutyl)acetamide - [AC79881] Ivosidenib (RG-120) RG 120(racemic) AG-120 racemic N-{1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-L-prolinamide Ivosidenib(racemic) RG120(racemic) (2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide |
| Description | IDH1 Inhibitor 8 (91) is isocitrate dehydrogenase 1 (IDH1) inhibitor. IDH1 Inhibitor 8 can be used for the research of cancer[1]. |
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| Related Catalog | |
| References |
[1]. Rene M, et al. Therapeutically active compounds and their methods of use. Patent. WO2013107291. |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 854.3±65.0 °C at 760 mmHg |
| Molecular Formula | C28H22ClF3N6O3 |
| Molecular Weight | 582.96 |
| Flash Point | 470.4±34.3 °C |
| Exact Mass | 582.139404 |
| PSA | 119.29000 |
| LogP | 0.38 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.651 |