1448346-63-1

• 常用中文名：1-(4-氰基-2-吡啶基)-5-氧代-L-脯氨酰-2-(2-氯苯基)-N-(3,3-二氟环丁基)-N2-(5-氟-3-吡啶基)甘氨酰胺
• 常用英文名：AG-120
• CAS号：1448346-63-1
• 分子式：C₂₈H₂₂ClF₃N₆O₃
• 分子量：582.96
• 相关类别： 信号通路 代谢酶/蛋白酶 异柠檬酸脱氢酶(IDH)
• 发布时间：2017-02-23 03:30:20
• 更新时间：2026-08-02 14:36:55
• IDH1 Inhibitor 8 (91) 是异柠檬酸脱氢酶 1 (IDH1) 抑制剂。 IDH1 Inhibitor 8 可用于癌症研究。

名称

• 中文名: 1-(4-氰基-2-吡啶基)-5-氧代-L-脯氨酰-2-(2-氯苯基)-N-(3,3-二氟环丁基)-N2-(5-氟-3-吡啶基)甘氨酰胺
• 英文名: (2S)-N-(1 -(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
• 中文别名: (S)-1-(4-氰基-2-吡啶基)-5-氧代-L-脯氨酰-2-(2-氯苯基)-N-(3,3-二氟环丁基)-N2-(5-氟-3-吡啶基)甘氨酰胺; 1-(4-氰基-2-吡啶基)-5-氧代-L-脯氨酰-2-(2-氯苯基)-N-(3,3-二氟环丁基)-N2-(5-氟-3-吡啶基)甘氨酰; 13C5]-IVOSIDENI,外消旋混合物; 1-(4-氰基-2-吡啶基)-5-氧代-L-脯氨酰-2-(2-氯苯基)-N-(3,3-二氟环丁基)-N2-(5-氟-3-吡啶基)甘氨酰胺 AG-120; 1-(4-氰基-2-吡啶基)-5-氧代-L; AG-120(外消旋); 抑制剂AG-120 Racemate; 脯氨酰-2-(2-氯苯基)-N-(3,3-二氟环丁基)-N2-(5-氟-3-吡啶基)甘氨酰胺 AG; AG-120 (racemic) 试剂; 脯氨酰-2-(2-氯苯基)-N-(3,3-二氟环丁基)-N2-(5-氟-3-吡啶基)甘氨酰胺 AG-120
• 英文别名: AG-120 Racemate; 1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide; AG120/Ivosidenib-API; Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl); Ivosideni, racemic mixture; AG 120 (racemic),AG120 (racemic); AG-120 (racemic), 10 mM in DMSO; 13C5]-Ivosideni, racemic mixture; (2S)-N-(1 -(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-cboxamide; 2-(2-chlorophenyl)-2-{1-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]-N-(5-fluoropyridin-3-yl)formamido}-N-(3,3-difluorocyclobutyl)acetamide; AG-120 Ivosidenib; (R,S)-Ivosidenib (AG-120); Ivosidenib (RG-120 racemic); RG-120(racemic); AG-120 (Ivosidenib) racemic; 2-(2-chlorophenyl)-2-{1-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]-N-(5-fluoropyridin-3-yl)formamido}-N-(3,3-difluorocyclobutyl)acetamide - [AC79881]; Ivosidenib (RG-120); RG 120(racemic); AG-120 racemic; N-{1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-L-prolinamide; Ivosidenib(racemic); RG120(racemic); (2S)-N-(1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 854.3±65.0 °C at 760 mmHg
• 分子式: C₂₈H₂₂ClF₃N₆O₃
• 分子量: 582.96
• 闪点: 470.4±34.3 °C
• 精确质量: 582.139404
• PSA: 119.29000
• LogP: 0.38
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.651
• 储存条件: 2-8°C，干燥密封

生物活性

• 描述: IDH1 Inhibitor 8 (91) 是异柠檬酸脱氢酶 1 (IDH1) 抑制剂。 IDH1 Inhibitor 8 可用于癌症研究。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 异柠檬酸脱氢酶(IDH)
• 参考文献:

  [1]. Rene M, et al. Therapeutically active compounds and their methods of use. Patent. WO2013107291.