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2586-96-1

2586-96-1 structure
2586-96-1 structure
  • Name: Liensinine
  • Chemical Name: Liensinine
  • CAS Number: 2586-96-1
  • Molecular Formula: C37H42N2O6
  • Molecular Weight: 610.739
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-04-16 08:00:00
  • Modify Date: 2024-01-02 10:53:03
  • Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc[1].

Name Liensinine
Synonyms 4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl]methyl}-2-{[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinyl]oxy}phenol
4-{[(1R)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-{[(1R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}phenol
Hiensinine
Phenol, 4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinyl]oxy]-
Description Liensinine is an autophagy/mitophagy inhibitor. Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc[1].
Related Catalog
References

[1]. Zhou J, et al. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy. 2015;11(8):1259-79.

Density 1.2±0.1 g/cm3
Boiling Point 722.0±60.0 °C at 760 mmHg
Melting Point 95-99ºC
Molecular Formula C37H42N2O6
Molecular Weight 610.739
Flash Point 390.4±32.9 °C
Exact Mass 610.304260
PSA 83.86000
LogP 4.84
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.618
Hazard Codes Xi