548-04-9

548-04-9 structure

Name: Hypericin
Chemical Name: hypericin
CAS Number: 548-04-9
Molecular Formula: C₃₀H₁₆O₈
Molecular Weight: 504.443
Catalog: Biochemical Natural product
Create Date: 2018-09-09 16:33:01
Modify Date: 2026-06-30 01:37:12
Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light.

Name	hypericin
Synonyms	Hypericin, 10 mM in DMSO HYPERICINRESECH ADE dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl ST.JOHNSWORTEXTRACT,4:1,POWDER D2-Hypericin Phenanthro [1,10,9,8-opqra]perylene-7,14 1,3,4,6,8,13-Hexahydroxy-10,11-dimethyl-7,14-dihydrophenanthro[1,10,9,8-opqra]perylene-7,14-dione MYCOPOPHYRIN Hypericins MYCOPORPHYRIN 1,3,4,6,8,13-HEXAHYDROXY-10,11-DIMETHYLPHENANTHROL(1,10,9,8,OPQRA)PERYLENE-7,14-DIONE Hypericin / 1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione / 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone Hypericinum Hyperici perforati 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenthro[1,10,9,8-opqra]perylene-7,14-dione St John S wort extract, hypericin Hypericin -9 STJOHN'SWORTHYPERICIN HYPERICIN(P) Hypericin, PKC inhibitor 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione P-conformer Hypericin, >= ST JOHN'S WORT POWDER Hypericin (SGX301) VIMRxyn ypericin Hypericin //BP HYPERICIN HPLC 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione 1,3,4,6,8,13-HEXAHYDROXY-10,11-DIMETHYLPHENANTHRO[1,10,9,8-OPQRA]PERYLENE-7,14-DIONE Hypericin, Cyclo-Werrol Hyperici 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone hypericinfromhypericumperforatum Hypericin - - Calbiochem ST JOHN'S WORT EXTRACT CYCLOSAN Hypericin CAS NO.-9 HYPERICUM RED HYPERICIN PubChem ID EINECS 208-941-0 Hypericin from Hypericum perforatum HYPERICIN (NATIVE) Cyclo-Werrol: Hypericum red Phenanthro1,10,9,8-opqraperylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-, stereoisomer Hypericine CYCLO-WERROL MFCD02100619 Hypericin-RM Hypericin Hypericum perforatum Cyclo werrol, Hypericum red, 4,5,7,4μ,5μ,7μ-Hexahydroxy-2,2μ-dimethylnaphthodianthrone Hypericin 1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione

Description	Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Others
References	[1]. Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34(3):221-41. [2]. Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62. [3]. Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21(4A):2649-55.

Density	1.9±0.1 g/cm3
Boiling Point	930.1±65.0 °C at 760 mmHg
Melting Point	299-301°C
Molecular Formula	C₃₀H₁₆O₈
Molecular Weight	504.443
Flash Point	530.1±30.8 °C
Exact Mass	504.084503
PSA	155.52000
LogP	8.39
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	2.131
Storage condition	Store at +4°C
Water Solubility	1 M NaOH: 10 mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H317
Precautionary Statements	P280-P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22
Safety Phrases	S22-S36
RIDADR	2811
WGK Germany	3
HS Code	2914700090

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

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