Hypericin

Modify Date: 2024-01-02 11:42:26

Hypericin Structure
Hypericin structure
 Common Name Hypericin
CAS Number 548-04-9 Molecular Weight 504.443
Density 1.9±0.1 g/cm3 Boiling Point 930.1±65.0 °C at 760 mmHg
Molecular Formula C30H16O8 Melting Point 299-301°C
MSDS Chinese USA Flash Point 530.1±30.8 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Hypericin


Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light.

 Names

Name hypericin
Synonym More Synonyms

 Hypericin Biological Activity

Description Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light.
Related Catalog
References

[1]. Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34(3):221-41.

[2]. Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62.

[3]. Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21(4A):2649-55.

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 930.1±65.0 °C at 760 mmHg
Melting Point 299-301°C
Molecular Formula C30H16O8
Molecular Weight 504.443
Flash Point 530.1±30.8 °C
Exact Mass 504.084503
PSA 155.52000
LogP 8.39
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 2.131
Storage condition Store at +4°C
Water Solubility 1 M NaOH: 10 mg/mL

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H317
Precautionary Statements P280-P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22
Safety Phrases S22-S36
RIDADR 2811
WGK Germany 3
HS Code 2914700090

 Customs

HS Code 2914700090
Summary HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

 Articles71

More Articles
Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium).

Fitoterapia 100 , 95-109, (2015)

In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Is...

Alterations in dysadherin expression and F-actin reorganization: a possible mechanism of hypericin-mediated photodynamic therapy in colon adenocarcinoma cells.

Cytotechnology 67(2) , 311-30, (2015)

Dysadherin is a recently found anti-adhesion molecule, therefore detection and down regulation of its expression is promising in cancer treatment. The up-regulation of dysadherin contributes to colon ...

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Drug Metab. Dispos. 36 , 1385-405, (2008)

We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...

 Synonyms

Phenanthro[1,10,9,8-opqra]perylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-
EINECS 208-941-0
1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
CYCLOSAN
Hypericin
MYCOPORPHYRIN
HYPERICUM RED
VIMRxyn
4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone
MYCOPOPHYRIN
CYCLO-WERROL
MFCD02100619
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