Hypericin
Hypericin structure
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Common Name | Hypericin | ||
|---|---|---|---|---|
| CAS Number | 548-04-9 | Molecular Weight | 504.443 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 930.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C30H16O8 | Melting Point | 299-301°C | |
| MSDS | Chinese USA | Flash Point | 530.1±30.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of HypericinHypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | hypericin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uMIn vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 930.1±65.0 °C at 760 mmHg |
| Melting Point | 299-301°C |
| Molecular Formula | C30H16O8 |
| Molecular Weight | 504.443 |
| Flash Point | 530.1±30.8 °C |
| Exact Mass | 504.084503 |
| PSA | 155.52000 |
| LogP | 8.39 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 2.131 |
| InChIKey | YDOIFHVUBCIUHF-UHFFFAOYSA-N |
| SMILES | Cc1cc(=O)c2c(O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(O)c7c(=O)cc(C)c8c1c2c(c34)c(c65)c78 |
| Storage condition | Store at +4°C |
| Water Solubility | 1 M NaOH: 10 mg/mL |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H317 |
| Precautionary Statements | P280-P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | S22-S36 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| HS Code | 2914700090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914700090 |
|---|---|
| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Phytochemical analysis and in vitro biological activity of three Hypericum species from the Canary Islands (Hypericum reflexum, Hypericum canariense and Hypericum grandifolium).
Fitoterapia 100 , 95-109, (2015) In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Is... |
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Alterations in dysadherin expression and F-actin reorganization: a possible mechanism of hypericin-mediated photodynamic therapy in colon adenocarcinoma cells.
Cytotechnology 67(2) , 311-30, (2015) Dysadherin is a recently found anti-adhesion molecule, therefore detection and down regulation of its expression is promising in cancer treatment. The up-regulation of dysadherin contributes to colon ... |
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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug Metab. Dispos. 36 , 1385-405, (2008) We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| EINECS 208-941-0 |
| 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione |
| CYCLOSAN |
| Hypericin |
| MYCOPORPHYRIN |
| HYPERICUM RED |
| VIMRxyn |
| 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone |
| MYCOPOPHYRIN |
| CYCLO-WERROL |
| MFCD02100619 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of hypericin? |
| A: CAS number of hypericin is 548-04-9. |
| Q: What is the melting point of hypericin? |
| A: Melting point of hypericin is 299-301°C. |
| Q: What are the storage conditions for hypericin? |
| A: Storage conditions for hypericin: Store at +4°C. |
| Q: What is the SMILES notation of hypericin? |
| A: SMILES notation of hypericin is Cc1cc(=O)c2c(O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(O)c7c(=O)cc(C)c8c1c2c(c34)c(c65)c78. |
| Q: What is the molecular formula of hypericin? |
| A: Molecular formula of hypericin is C30H16O8. |
| Q: What is the English name of hypericin? |
| A: The English name of hypericin is hypericin. |
| Q: What is the LogP of hypericin? |
| A: LogP of hypericin is 8.39. |
| Q: What is the InChIKey of hypericin? |
| A: InChIKey of hypericin is YDOIFHVUBCIUHF-UHFFFAOYSA-N. |
| Q: What is the molecular weight of hypericin? |
| A: Molecular weight of hypericin is 504.443. |
| Q: What is the boiling point of hypericin? |
| A: Boiling point of hypericin is 930.1±65.0 °C at 760 mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |
| Henan Tianfu Chemical Co., Ltd. |