Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (1S,4S)-(+)-2-(2,4-DIFLUORO-BENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE
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Purity: 98.0%
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84676-89-1

84676-89-1 structure

Name: Astragaloside II
Chemical Name: Astragaloside II
CAS Number: 84676-89-1
Molecular Formula: C₄₃H₇₀O₁₅
Molecular Weight: 827.01
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-06-10 06:47:10
Modify Date: 2024-01-02 09:34:51
Astragaloside II is a natural isolated from Astragalus.IC50 value:Target:In vitro:In vivo: The developed and validated method has been successfully applied to the quantification and pharmacokinetic study of AST II in rats after intravenous and oral administration of AST II. The oral absolute bioavailability (F) of AST II was calculated to be 0.79 ± 0.16% with an elimination half-life (t1/2) value of 1.92 ± 0.30 h, suggesting its poor absorption and/or strong metabolism in vivo [1].

Name	Astragaloside II
Synonyms	β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-3-[(2-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-14-methyl-9,19-cyclocholestan-6-yl Cyclosieversioside D (3β,6α,16β,20R,24S)-3-[(2-O-Acetyl-β-D-xylopyranosyl)oxy]-16,25-dihydroxy-14-methyl-20,24-epoxy-9,19-cyclocholestan-6-yl β-D-glucopyranoside AstrasieversianinVIII 16,25-dihydroxy-9,19-cyclolanostan-6-yl Astragaloside B Cyclosiversioside D

Description	Astragaloside II is a natural isolated from Astragalus.IC50 value:Target:In vitro:In vivo: The developed and validated method has been successfully applied to the quantification and pharmacokinetic study of AST II in rats after intravenous and oral administration of AST II. The oral absolute bioavailability (F) of AST II was calculated to be 0.79 ± 0.16% with an elimination half-life (t1/2) value of 1.92 ± 0.30 h, suggesting its poor absorption and/or strong metabolism in vivo [1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Terpenoids and Glycosides
References	[1]. Haijun Qu, et al. Quantification and pharmacokinetics of astragaloside II in rats by rapid liquid chromatography-tandem mass spectrometry. Anal. Methods, 2014,6, 6815-6822 [2]. Kong XH, et al. Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways. Int J Mol Med. 2012 Jun;29(6):1090-8. [3]. Huang C, et al. Reversal of P-glycoprotein-mediated multidrug resistance of human hepatic cancer cells by Astragaloside II. J Pharm Pharmacol. 2012 Dec;64(12):1741-50. [4]. Wan CP, et al. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity. Acta Pharmacol Sin. 2013 Apr;34(4):522-30.

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	29389090

Precursor 0
DownStream 2
84605-18-5 83207-58-3