Astragaloside II

Modify Date: 2024-01-02 09:34:51

Astragaloside II structure	Common Name	Astragaloside II
	CAS Number	84676-89-1	Molecular Weight	827.01
	Density	1.4±0.1 g/cm3	Boiling Point	896.9±65.0 °C at 760 mmHg
	Molecular Formula	C₄₃H₇₀O₁₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	265.3±27.8 °C

Use of Astragaloside II

Astragaloside II is a natural isolated from Astragalus.IC50 value:Target:In vitro:In vivo: The developed and validated method has been successfully applied to the quantification and pharmacokinetic study of AST II in rats after intravenous and oral administration of AST II. The oral absolute bioavailability (F) of AST II was calculated to be 0.79 ± 0.16% with an elimination half-life (t1/2) value of 1.92 ± 0.30 h, suggesting its poor absorption and/or strong metabolism in vivo [1].

Name	Astragaloside II
Synonym	More Synonyms

Description	Astragaloside II is a natural isolated from Astragalus.IC50 value:Target:In vitro:In vivo: The developed and validated method has been successfully applied to the quantification and pharmacokinetic study of AST II in rats after intravenous and oral administration of AST II. The oral absolute bioavailability (F) of AST II was calculated to be 0.79 ± 0.16% with an elimination half-life (t1/2) value of 1.92 ± 0.30 h, suggesting its poor absorption and/or strong metabolism in vivo [1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Natural Products >> Terpenoids and Glycosides
References	[1]. Haijun Qu, et al. Quantification and pharmacokinetics of astragaloside II in rats by rapid liquid chromatography-tandem mass spectrometry. Anal. Methods, 2014,6, 6815-6822 [2]. Kong XH, et al. Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways. Int J Mol Med. 2012 Jun;29(6):1090-8. [3]. Huang C, et al. Reversal of P-glycoprotein-mediated multidrug resistance of human hepatic cancer cells by Astragaloside II. J Pharm Pharmacol. 2012 Dec;64(12):1741-50. [4]. Wan CP, et al. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity. Acta Pharmacol Sin. 2013 Apr;34(4):522-30.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Terpenoids and Glycosides

References

[1]. Haijun Qu, et al. Quantification and pharmacokinetics of astragaloside II in rats by rapid liquid chromatography-tandem mass spectrometry. Anal. Methods, 2014,6, 6815-6822

[2]. Kong XH, et al. Astragaloside II induces osteogenic activities of osteoblasts through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways. Int J Mol Med. 2012 Jun;29(6):1090-8.

[3]. Huang C, et al. Reversal of P-glycoprotein-mediated multidrug resistance of human hepatic cancer cells by Astragaloside II. J Pharm Pharmacol. 2012 Dec;64(12):1741-50.

[4]. Wan CP, et al. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity. Acta Pharmacol Sin. 2013 Apr;34(4):522-30.

Density	1.4±0.1 g/cm3
Boiling Point	896.9±65.0 °C at 760 mmHg
Molecular Formula	C₄₃H₇₀O₁₅
Molecular Weight	827.01
Flash Point	265.3±27.8 °C
PSA	234.29000
LogP	0.80
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.615

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	29389090

Precursor 0
DownStream 2
CAS#:84605-18-5 Cycloastragenol CAS#:83207-58-3 Astragaloside A

β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-3-[(2-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-14-methyl-9,19-cyclocholestan-6-yl

Cyclosieversioside D

(3β,6α,16β,20R,24S)-3-[(2-O-Acetyl-β-D-xylopyranosyl)oxy]-16,25-dihydroxy-14-methyl-20,24-epoxy-9,19-cyclocholestan-6-yl β-D-glucopyranoside

AstrasieversianinVIII

16,25-dihydroxy-9,19-cyclolanostan-6-yl

Astragaloside B

Cyclosiversioside D

BioBioPha
China
Product Name: Astragaloside II
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Astragaloside II
Price: ￥658.0/10mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: astragalosideⅡ
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (1S,4S)-(+)-2-(2,4-DIFLUORO-BENZYL)-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $202/10mM*1mLinDMSO

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Astragaloside II

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