125697-93-0

125697-93-0 structure

Name: Lavendustin C
Chemical Name: lavendustin c
CAS Number: 125697-93-0
Molecular Formula: C₁₄H₁₃NO₅
Molecular Weight: 275.257
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2017-10-10 11:02:55
Modify Date: 2024-01-08 09:00:34
Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2].

Name	lavendustin c
Synonyms	5-[(2,5-Dihydroxybenzyl)amino]-2-hydroxybenzoic acid Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy- hdba compound 5

Description	Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Neuronal Signaling >> CaMK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
Target	CaMK II:0.2 μM (IC50) EGFR:0.012 μM (IC50)
In Vitro	Lavendustin C (Compound 5) shows potent inhibitory activity, and it may be the core structure responsible for inhibition of tyrosine kinase[1]. Lavendustin C (10-150 µM) inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation[3].
References	[1]. T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52(6):1252-7. [2]. T J O'Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353(6344):558-60. [3]. H M Burt, et al. Inhibition of Crystal-Induced Neutrophil Activation by a Protein Tyrosine Kinase Inhibitor. J Leukoc Biol. 1994 Jan;55(1):112-9.

1194-98-5

125697-93-0

89-57-6

125697-93-0

1194-98-5

89-57-6

125697-93-0

Precursor 2
1194-98-5 89-57-6
DownStream 0

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%