Lavendustin C
Modify Date: 2025-09-02 12:14:21
Lavendustin C structure
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Common Name | Lavendustin C | ||
|---|---|---|---|---|
| CAS Number | 125697-93-0 | Molecular Weight | 275.257 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 597.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C14H13NO5 | Melting Point | 193-195ºC dec. | |
| MSDS | Chinese USA | Flash Point | 315.2±30.1 °C | |
Use of Lavendustin CLavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2]. |
| Name | lavendustin c |
|---|---|
| Synonym | More Synonyms |
| Description | Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 µM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 µM) and pp60c-src(+) kinase (IC50=0.5 µM) [1][2]. |
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| Related Catalog | |
| Target |
CaMK II:0.2 μM (IC50) EGFR:0.012 μM (IC50) |
| In Vitro | Lavendustin C (Compound 5) shows potent inhibitory activity, and it may be the core structure responsible for inhibition of tyrosine kinase[1]. Lavendustin C (10-150 µM) inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation[3]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 597.5±50.0 °C at 760 mmHg |
| Melting Point | 193-195ºC dec. |
| Molecular Formula | C14H13NO5 |
| Molecular Weight | 275.257 |
| Flash Point | 315.2±30.1 °C |
| Exact Mass | 275.079376 |
| PSA | 110.02000 |
| LogP | 1.74 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.759 |
| InChIKey | LULATDWLDJOKCX-UHFFFAOYSA-N |
| SMILES | O=C(O)c1cc(NCc2cc(O)ccc2O)ccc1O |
| Storage condition | -20℃ |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| HS Code | 2922509090 |
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Lavendustin C CAS#:125697-93-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 37, # 24 p. 4079 - 4084 |
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Lavendustin C CAS#:125697-93-0 |
| Literature: Journal of Medicinal Chemistry, , vol. 37, # 24 p. 4079 - 4084 |
|
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Lavendustin C CAS#:125697-93-0 |
| Literature: Journal of Organic Chemistry, , vol. 61, # 26 p. 9368 - 9373 |
| Precursor 2 | |
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| DownStream 0 | |
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| 5-[(2,5-Dihydroxybenzyl)amino]-2-hydroxybenzoic acid |
| Benzoic acid, 5-[[(2,5-dihydroxyphenyl)methyl]amino]-2-hydroxy- |
| hdba |
| compound 5 |