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581-88-4

581-88-4 structure
581-88-4 structure
  • Name: DEBRISOQUIN SULFATE
  • Chemical Name: debrisoquin sulfate
  • CAS Number: 581-88-4
  • Molecular Formula: C10H13N3.1/2H2O4S
  • Molecular Weight: 224.27
  • Catalog: Chemical reagent Organic reagent Barium salt
  • Create Date: 2018-07-24 22:02:56
  • Modify Date: 2024-01-10 19:43:20
  • Debrisoquin (Isocaramidine) hemisulfate is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin hemisulfate can be used for antiviral research[1].

Name debrisoquin sulfate
Synonyms 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)
Debrisoquin hemisulfate
Bis[3,4-dihydroisoquinolin-2(1H)-yl(imino)methanaminium] sulfate
debrisoquine sulfate
3,4-Dihydroisoquinoline-2(1H)-carboximidamide sulfate (2:1)
3,4-Dihydro-2(1H)-isoquinolinecarboximidamide sulfate (2:1)
Debrisoquin sulfate
debrisoquine sulphate
Description Debrisoquin (Isocaramidine) hemisulfate is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin hemisulfate can be used for antiviral research[1].
Related Catalog
Target

Human Endogenous Metabolite

Boiling Point 309.8ºC at 760 mmHg
Melting Point 278-280°, 284-285° or 266-268° (H2O)
Molecular Formula C10H13N3.1/2H2O4S
Molecular Weight 224.27
Flash Point 141.1ºC
Exact Mass 448.189270
PSA 189.20000
LogP 3.78020
Storage condition -20°C Freezer
Water Solubility H2O: 20 mg/mL with heat

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NW7010000
CAS REGISTRY NUMBER :
581-88-4
LAST UPDATED :
198804
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C10-H13-N3.1/2H2-O4-S
MOLECULAR WEIGHT :
224.30
WISWESSER LINE NOTATION :
T66 CNT&J CYZUM & 2WSQQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
610 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 17,129,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
235 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
132 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
136 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
31700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 6,299,1964
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases 22
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NW7010000
HS Code 2933499090
HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%