DC Chemicals Limited
China
Product Name: Ansamitocin P-3
Price: $300.0/100mg $600.0/250mg $1200.0/1g
Purity: 98.0%
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Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ANSAMITOCIN P-3
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: ANSAMITOCIN P-3
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFUCHEM--66547-09-9---ANSAMITOCIN P-3
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

66547-09-9

66547-09-9 structure

66547-09-9 structure

Name: Ansamitocin P-3
Chemical Name: Ansamitocin P-3'
CAS Number: 66547-09-9
Molecular Formula: C₃₂H₄₃ClN₂O₉
Molecular Weight: 635.145
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-02-21 08:00:00
Modify Date: 2024-01-02 17:13:21
Ansamitocin P 3' exhibits antitumour activity, is an antibody drug conjugate cytotoxin. The more information please refer to Ansamitocin P-3 (HY-15739).

Name	Ansamitocin P-3'
Synonyms	maytansinol 3-butyrate Propanoic acid, 2-methyl-, (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10,12,1 4(26),16,18-pentaen-6-yl ester C32H43ClN2O9 Maytansinol butyrate (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1.0]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2- methylpropanoate Ansamitocin P-3 MFCD00274586 Ansamitocin P 3'

Description	Ansamitocin P 3' exhibits antitumour activity, is an antibody drug conjugate cytotoxin. The more information please refer to Ansamitocin P-3 (HY-15739).
Related Catalog	Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Research Areas >> Cancer
References	[1]. Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One. 2013 Oct 4;8(10):e75182.

Density	1.3±0.1 g/cm3
Boiling Point	833.1±65.0 °C at 760 mmHg
Melting Point	182-185℃
Molecular Formula	C₃₂H₄₃ClN₂O₉
Molecular Weight	635.145
Flash Point	457.7±34.3 °C
Exact Mass	634.265686
PSA	136.16000
LogP	5.09
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.583
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OQ2293000

CHEMICAL NAME :: Maytansine, 3-de(2-(acetylmethylamino)propionyloxy)-3-hydroxy-, butyrate (ester)

CAS REGISTRY NUMBER :: 66547-09-9

LAST UPDATED :: 199401

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C32-H43-Cl-N2-O9

MOLECULAR WEIGHT :: 635.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #78-130495

Hazard Codes	Xn
Risk Phrases	R20/22;R36/37/38
Safety Phrases	S26;S36
WGK Germany	3
RTECS	OQ2293000

57103-68-1 structure

57103-68-1

107-92-6 structure

107-92-6

~54%

66547-09-9 structure

66547-09-9

Literature: Kawai; Akimoto; Kozai; et al. Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 9 p. 3441 - 3451

Precursor 2
57103-68-1 107-92-6
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