Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dicyclohexano-18-crown-6
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Purity: 98.0%
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16069-36-6

16069-36-6 structure

Name: Dicyclohexyl 18-crown-6
Chemical Name: Dicyclohexano-18-crown-6
CAS Number: 16069-36-6
Molecular Formula: C₂₀H₃₆O₆
Molecular Weight: 372.496
Catalog: Chemical reagent Organic reagent Crown ether
Create Date: 2018-04-02 08:00:00
Modify Date: 2026-07-12 09:04:06

Name	Dicyclohexano-18-crown-6
Synonyms	k)(1,4,7,10,13,16)hexaoxacyclooctadecin,eicosahydro-dibenzo( 2,3,11,12-dicyclohexano-1,4,7,10,13,16-hexaoxacyclo-octadecane EINECS 240-216-4 k][1,4,7,10,13,16]hexaoxacyclooctadecin,eicosahydro-Dibenzo[b Dicyclohexo-18-crown-6 dicyclohexyl-18-crown-6 DICYCLOHEXANO-18-CROWN-6, MIXTURE OF ISO MERS Dibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecin, eicosahydro mixtureisomeres DICYCLOHEXANO-18-CROWN 6-ETHER cis-Dicyclohexano-18-crown-6, mixture of syn-cis and anti-cis isomers CIS-DICYCLOHEXANO-18-CROWN-6 EICOSAHYDRODIBENZO[B,K][1,4,7,10,13,16]HEXAOXACYCLOOCTADECIN 2,3,11,12-DICYCLOHEXANO-1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE 2,3:11,12-Dibutano-1,4,7,10,13,16-hexaoxacyclooctadecane cis-dicyclohexano-18-crown-6 1,2,3,4,4a,6,7,9,10,11a,12,13,14,15,15a,17,18,20,21,22a-Icosahydrodibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecin cis-Dicyclohexano-18-crown-6, cis-anti-cis isomer k][1,4,7,10,13,16]hexaoxacyclooctadecin,eicosahydro-dibenzo[ Dicyclohexano-18-crown6-Ether> 2,5,8,15,18,21-hexaoxatricyclo(20.4.0.0(sup9,14))hexacosane DICYCLOHEXANO-18-CROWN-6 CIS-DICYCLOHEXYL-18-CROWN-6 DICYCLOHEXYL-18-CROWN-6 Dicyclohexano-18-crown-6,2,3,11,12-Dicyclohexano-1,4,7,10,13,16-hexaoxacyclooctadecane, 2,5,8,15,18,21-Hexaoxatricyclo[20.4.0.09.14]hexacosane, Dicyclohexyl-18-crown-6, Perhydro-dibenzo-18-crown-6 Crown ether/Dicyclohexyl-18-crown-6 (mixture of cis- and trans-isomers) 2,3,11,12-Dicyclohexano-1,4,7,10,13,16-hexaoxacyclooctadecane, Dicyclohexyl-18-crown-6, Perhydro-dibenzo-18-crown-6, 2,5,8,15,18,21-Hexaoxatricyclo[20.4.0.09.14]hexacosane DCH-18-crown-6 DICYCLOHEXYL-18-CROWN-6-ETHER 2,5,8,15,18,21-HEXAOXATRICYCLO[20.4.0.0]HEXACOSANE MFCD00005099 Dicyclohexano-18-crown 6-Ether dicyclohexyl-18-crown-6-ether CIS-DICYCLOHEXANO-18-CROWN-6 MIXTU RE OF SYN-CIS AND ANTI-CIS PERHYDRO-DIBENZO-18-CROWN-6 dicyclohexano-18-crown-6 icosahydrodibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecin Dicyclohexano-18-crown-6, mixture of isomers CIS-DICYCLOHEXANO-18-CROWN-6, CIS-SYN-CIS ISOMER CROWN ETHER/DICYCLOHEXYL-18-CROWN-6 (MIX Cis-Dicyclohexano-18-crown-6 mixture of syn-cis and anti-cis isomers DICYCLOHEXANO-18-CROWN-6 MIXED ISOMERS Perhydro-dibenzo-18-crown-6,2,5,8,15,18,21-Hexaoxatricyclo[20.4.0.09.14]hexacosane Eicosahydro-5,8,11,16,19,22-hexaoxadibenzo[a,j]cyclooctadecene CROWN ETHER/DICYCLOHEXYL-18-CROWN-6 2,3,11,12-Dicyclohexano-1,4,7,10,13,16-hexaoxacyclooctadecane cis-Dicyclohexano-18-crown-6, Mixture of syn-cis and anti-cis isoMers, R d2-06 2,3,11,12-Dicyclohexano-1,4,7,10,13,16-hexaoxacyclooctadecene Icosahydrodibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecine Perhydrodibenzo-18-crown-6

Density	1.0±0.1 g/cm3
Boiling Point	508.0±45.0 °C at 760 mmHg
Melting Point	47-50 °C
Molecular Formula	C₂₀H₃₆O₆
Molecular Weight	372.496
Flash Point	203.8±28.6 °C
Exact Mass	372.251190
PSA	55.38000
LogP	2.28
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.443
Storage condition	2-8°C
Water Solubility	Slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP5385000

CHEMICAL NAME :: Dibenzo(b,k)(1,4,7,10,13,16)hexaoxacyclooctadecin, eicosahydro-

CAS REGISTRY NUMBER :: 16069-36-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C20-H36-O6

MOLECULAR WEIGHT :: 372.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 176 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,408,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 192 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),72,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571202 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4575 mg/kg/61D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),72,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 mg/kg/26W-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),72,1987 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 105 mg/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),72,1987

Hazard Codes	T:Toxic;
Risk Phrases	R23/24/25;R36/37/38
Safety Phrases	S26-S36/37/39-S45-S38-S28A
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	HP5385000
Packaging Group	III
Hazard Class	6.1
HS Code	29329995

14187-32-7

16069-36-6

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 6 p. 1309 - 1313,1163 - 1166

931-17-9

111-44-4

~40%

16069-36-6

Literature: Yakshin, V. V.; Zhukova, N. G.; Tsarenko, N. A.; Laskorin, B. N. Doklady Chemistry, 1983 , vol. 273, p. 436 - 438 Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 273, # 6 p. 1398 - 1400

1460-57-7

16069-36-6

Literature: Russian Journal of Organic Chemistry, , vol. 29, # 7.2 p. 1234 - 1236 Zhurnal Organicheskoi Khimii, , vol. 29, # 7 p. 1485 - 1488

342422-42-8

75503-88-7

~20%

16069-36-6

Literature: Yakshin, V. V.; Zhukova, N. G.; Tsarenko, N. A.; Laskorin, B. N. Doklady Chemistry, 1983 , vol. 273, p. 436 - 438 Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 273, # 6 p. 1398 - 1400

1121-21-7

111-46-6

~10%

16069-36-6

Literature: Yakshin, V. V.; Zhukova, N. G.; Tsarenko, N. A.; Laskorin, B. N. Doklady Chemistry, 1983 , vol. 273, p. 436 - 438 Dokl. Akad. Nauk SSSR Ser. Khim., 1983 , vol. 273, # 6 p. 1398 - 1400

Precursor 8
14187-32-7 931-17-9 111-44-4 1460-57-7
342422-42-8 75503-88-7 1121-21-7 111-46-6
DownStream 0

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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