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539-21-9

539-21-9 structure
539-21-9 structure
  • Name: Ambazone
  • Chemical Name: Ambazone
  • CAS Number: 539-21-9
  • Molecular Formula: C8H11N7S
  • Molecular Weight: 237.28
  • Catalog: Chemical reagent Organic reagent
  • Create Date: 2018-05-13 08:00:00
  • Modify Date: 2024-01-02 17:25:34
  • Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities[1].

Name Ambazone
Synonyms [1,4]Benzochinon-carbamimidoylhydrazon-thiosemicarbazon
Ambazona [inn-spanish]
Benzoqu
anginon
Faringosept
ambazon
[1,4]benzoquinone-carbamimidoylhydrazone thiosemicarbazone
promassol
primal
Benzochinon-(1,4)-monoguanylhydrazon-monothiosemicarbazon
Ambazona
Inversal
Description Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities[1].
Related Catalog
References

[1]. G Löber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300.  

Density 1.57g/cm3
Boiling Point 461.9ºC at 760mmHg
Melting Point 195°C (rough estimate)
Molecular Formula C8H11N7S
Molecular Weight 237.28
Flash Point 233.2ºC
Exact Mass 237.08000
PSA 156.76000
LogP 1.42280
Index of Refraction 1.761

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF5550000
CHEMICAL NAME :
Guanidine, ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-, thiosemicarbazone
CAS REGISTRY NUMBER :
539-21-9
LAST UPDATED :
199712
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C8-H11-N7-S
MOLECULAR WEIGHT :
237.32
WISWESSER LINE NOTATION :
SUYZMNU- AL6Y DYJ DUNMYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
315 mg/kg/5D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
840 mg/kg/28D-I
TOXIC EFFECTS :
Gastrointestinal - other changes Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
625 mg/kg/5D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Microorganism - not otherwise specified
DOSE/DURATION :
10 gm/L
REFERENCE :
STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 117,99,1987
HS Code 2930909090

~%

539-21-9 structure

539-21-9

Literature: Pharmazie, , vol. 45, # 1 p. 41 - 42

~%

539-21-9 structure

539-21-9

Literature: Angewandte Chemie, , vol. 67, p. 217,219
Precursor  3

DownStream  0

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%