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539-21-9

539-21-9 structure

539-21-9 structure

Name: Ambazone
Chemical Name: Ambazone
CAS Number: 539-21-9
Molecular Formula: C₈H₁₁N₇S
Molecular Weight: 237.28
Catalog: Chemical reagent Organic reagent 腙
Create Date: 2018-05-13 08:00:00
Modify Date: 2026-07-16 12:16:04
Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities[1].

Name	Ambazone
Synonyms	ambazon 1-amidinohydrazono-4-thiosemicbazono-2,5-cyclohexadiene primal p-benzoquinone amidinohydrazone thiosemicbazone Ambazona anginon 1,4-Benzoquinone guanylhydrazone thiosemicbazone ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-guanidin thiosemicbazone benzoquinone guanylhydrazone thiosemicbazone [1,4]Benzochinon-carbamimidoylhydrazon-thiosemicarbazon Ambazone [inn:ban:dcf] Ambazone, 10 mM in DMSO Hydrazinecbothioamide, 2-[4-[2-(aminoiminomethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene] 4-Amidinohydrazono-2,5-cyclohexadien-1-on-thiosemicbazon Inversal promassol Fingost [1,4]benzoquinone-carbamimidoylhydrazone thiosemicarbazone [4-(2-(Diaminomethylidene)hydrazinyl)phenyl]iminothiourea Faringosept Benzochinon-(1,4)-monoguanylhydrazon-monothiosemicarbazon 1,4-Benzoquinone AMidinohydrazone ThioseMicbazone ambazone ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)guanidine thiosemicbazone Ambazona [inn-spanish] 2-[4-[2-(AMinoiMinoMethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]-hydrazinecbothioaMide Benzoqu

Description	Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. G Löber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300.

Density	1.57g/cm3
Boiling Point	461.9ºC at 760mmHg
Melting Point	195°C (rough estimate)
Molecular Formula	C₈H₁₁N₇S
Molecular Weight	237.28
Flash Point	233.2ºC
Exact Mass	237.08000
PSA	156.76000
LogP	1.42280
Index of Refraction	1.761

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF5550000

CHEMICAL NAME :: Guanidine, ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-, thiosemicarbazone

CAS REGISTRY NUMBER :: 539-21-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H11-N7-S

MOLECULAR WEIGHT :: 237.32

WISWESSER LINE NOTATION :: SUYZMNU- AL6Y DYJ DUNMYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 315 mg/kg/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg/28D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg/5D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 10 gm/L

REFERENCE :: STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 117,99,1987

HS Code	2930909090

61566-17-4 structure

61566-17-4

~%

539-21-9 structure

539-21-9

Literature: Pharmazie, , vol. 45, # 1 p. 41 - 42

7316-92-9 structure

7316-92-9

79-19-6 structure

79-19-6

~%

539-21-9 structure

539-21-9

Literature: Angewandte Chemie, , vol. 67, p. 217,219

Precursor 3
61566-17-4 7316-92-9 79-19-6
DownStream 0

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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