539-21-9

• 常用中文名：安巴腙
• 常用英文名：Ambazone
• CAS号：539-21-9
• 分子式：C₈H₁₁N₇S
• 分子量：237.28
• 相关类别： 化学试剂 有机试剂 腙
• 发布时间：2018-05-13 08:00:00
• 更新时间：2026-07-16 12:16:04
• Ambazone是一种口服活性膜活性抗肿瘤剂。Ambazone也显示出抗菌和较弱的抗病毒活性[1]。

名称

• 中文名: 安巴腙
• 英文名: Ambazone
• 中文别名: 硫脲胍腙; 双硫脲咪腙; 安巴腙,10 MM DMSO 溶液; 1-脒腙基-4-缩氨基硫脲-2,5-环己二烯
• 英文别名: ambazon; 1-amidinohydrazono-4-thiosemicbazono-2,5-cyclohexadiene; primal; p-benzoquinone amidinohydrazone thiosemicbazone; Ambazona; anginon; 1,4-Benzoquinone guanylhydrazone thiosemicbazone; ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-guanidin thiosemicbazone; benzoquinone guanylhydrazone thiosemicbazone; [1,4]Benzochinon-carbamimidoylhydrazon-thiosemicarbazon; Ambazone [inn:ban:dcf]; Ambazone, 10 mM in DMSO; Hydrazinecbothioamide, 2-[4-[2-(aminoiminomethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]; 4-Amidinohydrazono-2,5-cyclohexadien-1-on-thiosemicbazon; Inversal; promassol; Fingost; [1,4]benzoquinone-carbamimidoylhydrazone thiosemicarbazone; [4-(2-(Diaminomethylidene)hydrazinyl)phenyl]iminothiourea; Faringosept; Benzochinon-(1,4)-monoguanylhydrazon-monothiosemicarbazon; 1,4-Benzoquinone AMidinohydrazone ThioseMicbazone; ambazone; ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)guanidine thiosemicbazone; Ambazona [inn-spanish]; 2-[4-[2-(AMinoiMinoMethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]-hydrazinecbothioaMide; Benzoqu

物化性质

• 密度: 1.57g/cm3
• 沸点: 461.9ºC at 760mmHg
• 熔点: 195°C (rough estimate)
• 分子式: C₈H₁₁N₇S
• 分子量: 237.28
• 闪点: 233.2ºC
• 精确质量: 237.08000
• PSA: 156.76000
• LogP: 1.42280
• 外观性状: 固体
• 折射率: 1.761
• 储存条件: 库房通风低温干燥

生物活性

• 描述: Ambazone是一种口服活性膜活性抗肿瘤剂。Ambazone也显示出抗菌和较弱的抗病毒活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. G Löber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MF5550000 CHEMICAL NAME : Guanidine, ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-, thiosemicarbazone CAS REGISTRY NUMBER : 539-21-9 LAST UPDATED : 199712 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C8-H11-N7-S MOLECULAR WEIGHT : 237.32 WISWESSER LINE NOTATION : SUYZMNU- AL6Y DYJ DUNMYZUM HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 315 mg/kg/5D-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 840 mg/kg/28D-I TOXIC EFFECTS : Gastrointestinal - other changes Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 625 mg/kg/5D-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain MUTATION DATA TYPE OF TEST : DNA repair TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 10 gm/L REFERENCE : STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 117,99,1987

安全

• 海关编码: 2930909090

合成路线

61566-17-4 ~% 539-21-9

文献：Pharmazie, , vol. 45, # 1 p. 41 - 42

7316-92-9 79-19-6 ~% 539-21-9

文献：Angewandte Chemie, , vol. 67, p. 217,219

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61566-17-4 7316-92-9 79-19-6
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海关

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%