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1135-23-5

1135-23-5 structure
1135-23-5 structure
  • Name: dihydroferulic acid
  • Chemical Name: 3-(4-hydroxy-3-methoxyphenyl)propionic acid
  • CAS Number: 1135-23-5
  • Molecular Formula: C10H12O4
  • Molecular Weight: 196.200
  • Catalog: Flavors and spices Synthetic spice Aromatic cinnamic acid, esters and derivatives
  • Create Date: 2018-03-08 08:00:00
  • Modify Date: 2024-01-06 01:07:38
  • Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid[1][2].
Name 3-(4-hydroxy-3-methoxyphenyl)propionic acid
Synonyms Benzenepropanoic acid, 4-hydroxy-3-methoxy-
EINECS 214-489-5
3-(4-Hydroxy-3-methoxyphenyl)propanoic acid
dihydroferulic acid
3-(4-Hydroxy-3-Methoxyphenyl)propionic Acid
MFCD00016558
Description Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid[1][2].
Related Catalog
In Vitro Uptake of hydroxycinnamic acids by control, organic anion transporter 1 (OAT1), OAT2, OAT3, and OAT4 over expressing 293H cells. In 293H control cells, there was significant uptake of Dihydroferulic acid. The uptake of Dihydroferulic acid is also enhanced ~2-fold in the OAT1-expressing cells[3].
In Vivo Assessing the influence of an 11 weeks intervention with a resistant starch-enriched whole grain diet (HI-RS-WG, 25% RS) compared to a WG control diet (LOW-RS-WG, 6.9% RS) on serum profile of polyphenols (PPs) in 20 Zucker Diabetic Fatty rats. Five PPs were identified and quantified in serum samples of rats belonging to both intervention groups. HI-RS-WG rats had 2.6 folds higher serum concentrations of total PPs than LOW-RS-WG rats. An explorative data reduction approach, based on the Principal Component Analysis identified two principal components related to the gut microbiota fermentation and food intake, respectively. Results showed that the abundance of hippuric acid and Dihydroferulic acid in HI-RS-WG rats was explained by the stronger gut microbiota fermentation in those rats than in LOW-RS-WG rats[4].
References

[1]. Deters M, et al. Different curcuminoids inhibit T-lymphocyte proliferation independently of their radical scavenging activities. Pharm Res. 2008 Aug;25(8):1822-7.

[2]. Beck JJ, et al. Fungicidal activities of dihydroferulic acid alkyl ester analogues. J Nat Prod. 2007 May;70(5):779-82.

[3]. Wong CC, et al. Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters. Mol Nutr Food Res. 2011 Jul;55(7):979-88.

[4]. Paola Vitaglionea, et al. Gut fermentation induced by a resistant starch rich whole grain diet explains serum concentration of dihydroferulic acid and hippuric acid in a model of ZDF rats. Journal of Functional Foods. 53 (2019): 286-291.
Density 1.3±0.1 g/cm3
Boiling Point 376.5±27.0 °C at 760 mmHg
Melting Point 87-93 °C
Molecular Formula C10H12O4
Molecular Weight 196.200
Flash Point 151.1±17.2 °C
Exact Mass 196.073563
PSA 66.76000
LogP 0.81
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.562
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 2
HS Code 2918990090
HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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