217099-43-9

217099-43-9 structure

Name: BCX 1470
Chemical Name: (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate
CAS Number: 217099-43-9
Molecular Formula: C₁₄H₁₀N₂O₂S₂
Molecular Weight: 302.371
Catalog: Signaling Pathways Immunology/Inflammation Complement System
Create Date: 2018-12-30 17:25:48
Modify Date: 2024-01-10 15:31:03
BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.

Name	(2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate
Synonyms	2-Carbamimidoyl-1-benzothiophen-6-yl 2-thiophenecarboxylate 2-Thiophenecarboxylic acid, 2-(aminoiminomethyl)benzo[b]thien-6-yl ester BCX 1470\|\|BCX 1470\|BCX-1470 BCX 1470 CS-0313 2-carbamimidoyl-1-benzothiophen-6-yl thiophene-2-carboxylate 2-Carbamimidoyl-1-benzothiophen-6-ylthiophen-2-carboxylat cc-543

Description	BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Complement System Research Areas >> Inflammation/Immunology
References	[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468