BCX 1470

Modify Date: 2024-01-10 15:31:03

BCX 1470 Structure
BCX 1470 structure
Common Name BCX 1470
CAS Number 217099-43-9 Molecular Weight 302.371
Density 1.5±0.1 g/cm3 Boiling Point 509.9±58.0 °C at 760 mmHg
Molecular Formula C14H10N2O2S2 Melting Point N/A
MSDS N/A Flash Point 262.2±32.3 °C

 Use of BCX 1470


BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.

 Names

Name (2-carbamimidoyl-1-benzothiophen-6-yl) thiophene-2-carboxylate
Synonym More Synonyms

 BCX 1470 Biological Activity

Description BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.
Related Catalog
References

[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 509.9±58.0 °C at 760 mmHg
Molecular Formula C14H10N2O2S2
Molecular Weight 302.371
Flash Point 262.2±32.3 °C
Exact Mass 302.018372
PSA 132.65000
LogP 3.71
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.751
Storage condition 2-8℃

 Synonyms

2-Carbamimidoyl-1-benzothiophen-6-yl 2-thiophenecarboxylate
2-Thiophenecarboxylic acid, 2-(aminoiminomethyl)benzo[b]thien-6-yl ester
BCX 1470||BCX 1470|BCX-1470
BCX 1470
CS-0313
2-carbamimidoyl-1-benzothiophen-6-yl thiophene-2-carboxylate
2-Carbamimidoyl-1-benzothiophen-6-ylthiophen-2-carboxylat
cc-543
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