1093978-89-2
1093978-89-2 structure
- Name: gamma-secretase modulator 2
- Chemical Name: 6-fluoro-3-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one
- CAS Number: 1093978-89-2
- Molecular Formula: C25H22F4N6O2
- Molecular Weight: 514.47500
- Catalog: Signaling Pathways Neuronal Signaling γ-secretase
- Create Date: 2018-12-30 20:47:52
- Modify Date: 2026-07-08 10:03:49
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gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's diseaseIC50 value: Target: γ-secretaseγ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.
| Name | 6-fluoro-3-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one |
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| Synonyms |
gaMMa-secretase Modulator 2
2H-1-Benzopyran-2-carbonitrile,6-fluoro-3,4-dihydro-4-oxo 6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one gamma secretase modulator 2,gammasecretase modulator 2 6-fluoro-1,3,4,5-tetrahydro-3-[4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-2H-1-Benzazin-2-on 6-Fluoro-1,3,4 ,5-tetrahydro-3-[4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1 ,2,3-triazol-1-yl]-1-(2-trifluoroethyl)-2H-1-benzazin-2-one 6-Fluoro-1,3,4,5-tetrahydro-3-[4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-2H-1-Benzazin-2-one Merck gamma-secretase modulator Merck γ-secretase Modulator 6-Fluoro-1,3,4,5-tetrahydro-3-[4-[3-Methoxy-4-(4-Methyl-1H-iMidazol-1-yl)phenyl]-1H-1,2,3-triazol-1 6-fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carbonitrile 2H-1-BENZAZIN-2-ONE 6-FLUORO-1,3,4,5-TETRAHYDRO-3-[4-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)PHENYL]-1H-1,2,3-TRIAZOL-1-YL]-1-(2,2,2-TRIFLUOROETHYL) |
| Description | gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's diseaseIC50 value: Target: γ-secretaseγ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease. |
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| Related Catalog |
| Density | 1.43 g/cm3 |
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| Boiling Point | 729.8ºC at 760 mmHg |
| Molecular Formula | C25H22F4N6O2 |
| Molecular Weight | 514.47500 |
| Flash Point | 395.2ºC |
| Exact Mass | 514.17400 |
| PSA | 78.07000 |
| LogP | 4.73470 |
| Storage condition | 2-8℃ |
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1093978-89-2 |
| Literature: WO2008/156580 A1, ; Page/Page column 43-44 ; WO 2008/156580 A1 |
| Precursor 2 | |
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| DownStream 0 | |