1093978-89-2
1093978-89-2 structure
- Name: gamma-secretase modulator 2
- Chemical Name: 6-fluoro-3-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one
- CAS Number: 1093978-89-2
- Molecular Formula: C25H22F4N6O2
- Molecular Weight: 514.47500
- Catalog: Signaling Pathways Neuronal Signaling γ-secretase
- Create Date: 2018-12-30 20:47:52
- Modify Date: 2025-09-05 18:10:58
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gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's diseaseIC50 value: Target: γ-secretaseγ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.
| Name | 6-fluoro-3-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one |
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| Synonyms |
2H-1-Benzopyran-2-carbonitrile,6-fluoro-3,4-dihydro-4-oxo
6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 6-fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carbonitrile gamma-secretase modulator 2 |
| Description | gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's diseaseIC50 value: Target: γ-secretaseγ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease. |
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| Related Catalog |
| Density | 1.43 g/cm3 |
|---|---|
| Boiling Point | 729.8ºC at 760 mmHg |
| Molecular Formula | C25H22F4N6O2 |
| Molecular Weight | 514.47500 |
| Flash Point | 395.2ºC |
| Exact Mass | 514.17400 |
| PSA | 78.07000 |
| LogP | 4.73470 |
| Storage condition | 2-8℃ |
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~%
1093978-89-2 |
| Literature: WO2008/156580 A1, ; Page/Page column 43-44 ; WO 2008/156580 A1 |
| Precursor 2 | |
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| DownStream 0 | |