61379-65-5
61379-65-5 structure
- Name: Rifapentine
- Chemical Name: rifapentine
- CAS Number: 61379-65-5
- Molecular Formula: C47H64N4O12
- Molecular Weight: 877.031
- Catalog: API Antibiotics Rifamycin
- Create Date: 2018-08-12 23:05:31
- Modify Date: 2026-07-23 10:03:51
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Rifapentine (Priftin; DL 473) is an antibiotic compound used in the treatment of tuberculosis.Target: AntibacterialRifapentine inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. A review of alternative regimens for prevention of active tuberculosis in HIV-negative individuals with latent TB found that a weekly, directly observed regimen of rifapentine with isoniazid for three months was as effective as a daily, self -administered regimen of isoniazid for nine months. But the rifapentine-isoniazid regimen had higher rates of treatment completion and lower rates of hepatotoxicity . However the rates of treatment-limiting adverse events were higher in the rifapentine-isoniazid regimen [1].
| Name | rifapentine |
|---|---|
| Synonyms |
D8-Rifapentine
Rifapentine //BP rifamycin-S Rifapentine, 10 mM in DMSO D9-Rifapentine KTC-1 Cells Line Cyclopentyifampicin mdl473 Priftin RIFAPENTINE 3-[[(4-Cy-dopentyl-1piperazinyl)imino]methyl]rifamycin Rifapentinum 3-(4-cyclopentyl-1-piperazinyl)iminomethyifamycinsv 3{[(4-cyclopentyl-1-piperazinyl)imino]methyl}rifamycin Rifapention Rifamycin, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl) Rifapentine, (HPLC) 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)-rifamyci 3-[(4-Cyclopentylpiperazino)iminomethyl]rifamycin PIFAPENTINE Rifapenti Rifapentin Rifapentina rifamycinaf/ap r-773 ktc1 Rifamycin-B-tripropyl-hydrazid (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-{[(4-Cyclopentyl-1-piperazinyl)imino]methyl}-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracy ;clo[23.3.1.1.0]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate Prifitin antibioticdl473it Rifapentine(Priftin) (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-htamethyl-2,7-oxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione EINECS 262-743-9 dl473 rifamycin-B tripropylhydrazide 3 & 4-NONENES & 4-NONANOL |
| Description | Rifapentine (Priftin; DL 473) is an antibiotic compound used in the treatment of tuberculosis.Target: AntibacterialRifapentine inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. A review of alternative regimens for prevention of active tuberculosis in HIV-negative individuals with latent TB found that a weekly, directly observed regimen of rifapentine with isoniazid for three months was as effective as a daily, self -administered regimen of isoniazid for nine months. But the rifapentine-isoniazid regimen had higher rates of treatment completion and lower rates of hepatotoxicity . However the rates of treatment-limiting adverse events were higher in the rifapentine-isoniazid regimen [1]. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 969.3±65.0 °C at 760 mmHg |
| Melting Point | 179-180ºC |
| Molecular Formula | C47H64N4O12 |
| Molecular Weight | 877.031 |
| Flash Point | 540.0±34.3 °C |
| Exact Mass | 876.452087 |
| PSA | 216.66000 |
| LogP | 2.58 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.625 |
| Storage condition | -20°C Freezer |
| Water Solubility | methanol: soluble2mg/mL, clear, red to red-brown |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| RTECS | JQ0902000 |
| HS Code | 2941903000 |
| HS Code | 2941903000 |
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