61379-65-5

• 常用中文名：利福喷丁
• 常用英文名：Rifapentine
• CAS号：61379-65-5
• 分子式：C₄₇H₆₄N₄O₁₂
• 分子量：877.031
• 相关类别： 原料药 抗生素类药物 利福霉素类药
• 发布时间：2018-08-12 23:05:31
• 更新时间：2026-07-23 10:03:51
• Rifapentine (Priftin; DL 473)是抗生素,可用于肺结核。

名称

• 中文名: 利福喷丁
• 英文名: rifapentine
• 中文别名: 环戊哌嗪利福霉素; 利福喷汀; KTC-1人甲状腺癌细胞(乳头状); 利福喷汀-[D9]/精确称量; 环戊利福平、利福喷叮、利福喷汀; KTC-1人甲状腺癌细胞代次低|培养基|送STR图谱; 人甲状腺癌细胞(乳头状)(活细胞顺丰包邮,或可提供冻存管); 3-(4-环戊基-1-哌嗪基-亚氨甲基)-利福霉素; 环戊基哌嗪利福霉素; KTC-1(人甲状腺癌细胞)YB-71649HC; KTC-1细胞 (人甲状腺癌细胞) (STR鉴定正确)CL-0649; KTC-1人甲状腺癌细胞实验室|已有STR图谱; 环戊利福平; KTC-1+LUC+GFP人甲状腺癌细胞+LUC+GFP; 3-[4-环戊基-1-哌嗪基-亚氨基甲基]利福霉素; 利福喷汀-[D8]/精确称量; 氘9-利福喷丁; KTC-1 细胞| KTC-1 人甲状腺癌细胞; Rifapentine (Priftin) 10mM * 1mL in DMSO试剂; 环戊去甲利福平; 抑制剂Rifapentine; 利福喷丁(标准品); KTC-1:人甲状腺癌传代细胞; 人甲状腺癌细胞KTC1; 利福喷叮; KTC-1细胞 (人甲状腺癌细胞) (STR鉴定正确); KTC-1人甲状腺癌复苏细胞(附STR鉴定报告); KTC-1细胞(甲状腺癌细胞STR鉴定正确)LM8C0649; KTC-1 人甲状腺癌细胞系; 氘8-利福喷丁; KTC-1人甲状腺癌细胞新批次|培养基|送STR图谱; Rifapentine利福喷丁; 利福喷丁/利福喷汀 Rifapentine; 利福喷丁对照品; KTC-1人甲状腺癌细胞库|培养基|带STR图谱; (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-3-(((4-环戊基-1-哌嗪基)亚氨基)-甲基)-21-(乙酰氧基)-5,6,9,17,19-五羟基-23-甲氧基-2,4,12,16,18,20,22-庚甲基-2,7-(环氧戊基[1,11,13]三亚氨基)萘[2,1-B]呋喃-1,11(2H)-二酮; KTC-1+LUC+RFP人甲状腺癌细胞+LUC+RFP; 利福喷丁,10 MM DMSO 溶液
• 英文别名: D8-Rifapentine; Rifapentine //BP; rifamycin-S; Rifapentine, 10 mM in DMSO; D9-Rifapentine; KTC-1 Cells Line; Cyclopentyifampicin; mdl473; Priftin; RIFAPENTINE; 3-[[(4-Cy-dopentyl-1piperazinyl)imino]methyl]rifamycin; Rifapentinum; 3-(4-cyclopentyl-1-piperazinyl)iminomethyifamycinsv; 3{[(4-cyclopentyl-1-piperazinyl)imino]methyl}rifamycin; Rifapention; Rifamycin, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl); Rifapentine, (HPLC); 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)-rifamyci; 3-[(4-Cyclopentylpiperazino)iminomethyl]rifamycin; PIFAPENTINE; Rifapenti; Rifapentin; Rifapentina; rifamycinaf/ap; r-773; ktc1; Rifamycin-B-tripropyl-hydrazid; (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-{[(4-Cyclopentyl-1-piperazinyl)imino]methyl}-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracy ;clo[23.3.1.1.0]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate; Prifitin; antibioticdl473it; Rifapentine(Priftin); (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-htamethyl-2,7-oxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione; EINECS 262-743-9; dl473; rifamycin-B tripropylhydrazide; 3 & 4-NONENES & 4-NONANOL

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 969.3±65.0 °C at 760 mmHg
• 熔点: 179-180ºC
• 分子式: C₄₇H₆₄N₄O₁₂
• 分子量: 877.031
• 闪点: 540.0±34.3 °C
• 精确质量: 876.452087
• PSA: 216.66000
• LogP: 2.58
• 外观性状: 红色-棕色结晶粉末
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.625
• 储存条件: -20°C Freezer
• 水溶解性: methanol: soluble2mg/mL, clear, red to red-brown
• 分子结构:

  1、 摩尔折射率：229.12

  2、 摩尔体积（cm³/mol）：648.0

  3、 等张比容（90.2K）：1717.2

  4、 表面张力（dyne/cm）：49.3

  5、 极化率（10-24cm3）：90.83

• 更多:

  1.性状：从乙酸乙酯结晶。

  2.熔点：179～180℃。

  3.UV最大吸收：475，334nm(ε15200，26700)。

生物活性

• 描述: Rifapentine (Priftin; DL 473)是抗生素,可用于肺结核。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Sharma, S.K., et al., Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB. Cochrane Database Syst Rev, 2013. 7: p. CD007545.

毒性和生态

毒理学数据: 急性毒性LD50小鼠(mg/kg)：＞2000口服，750腹腔注射。也有报道急性毒性LD50小鼠(mg/kg)：3300口服，710腹腔注射。 CHEMICAL IDENTIFICATION RTECS NUMBER : JQ0902000 CHEMICAL NAME : Rifamycin, 3-(((4-cyclopentyl-1-piperazinyl)imino)methyl)- CAS REGISTRY NUMBER : 61379-65-5 LAST UPDATED : 199712 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C47-H64-N4-O12 MOLECULAR WEIGHT : 877.15 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,242,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 27,242,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1026,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 34,1026,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 140 ug/kg/7D-I TOXIC EFFECTS : Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Metabolism (Intermediary) - other proteins REFERENCE : ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 26,720,1991

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport
• RTECS号: JQ0902000
• 海关编码: 2941903000

制备

0.01ml的3-醛基利福霉素SV溶于四氢呋喃，在室温下加入0.011mol的1-氨基-4-环戊基哌嗪。反应用薄层跟踪，至原料点消失，约需麟。蒸去溶剂，剩余物用乙酸乙酯重结晶，得利福喷汀，收率55%，熔点179～180℃。

海关

海关编码	2941903000