3301-79-9
3301-79-9 structure
- Name: 6-Carboxyfluorescein
- Chemical Name: 6-carboxyfluorescein
- CAS Number: 3301-79-9
- Molecular Formula: C21H12O7
- Molecular Weight: 376.316
- Catalog: Dye Reagents
- Create Date: 2018-08-01 13:35:08
- Modify Date: 2026-07-03 09:30:55
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The single isomer, 6-FAM, contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. In addition to its relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility, fluorescein has an excitation maximum that closely matches the 488 nm spectral line of the argon-ion laser.
| Name | 6-carboxyfluorescein |
|---|---|
| Synonyms |
(3,6,9-Trihydroxyxanthen-9-yl)terhthalic Acid
Fluorescein, 6-cboxy 6-carboxy-fluorescein 6-FAM, FLUOS 6-cboxy' Uorescein 3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-cboxylic acid 3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid 6-FAM [6-Cboxyfluorescein] Cboxyfluorescein MFCD00036873 6-Cboxyfluorescein Terhthalicacid, (3,6,9-trihydroxyxanthen-9-yl)-, Γ-lactone 6-FAM FLUOS 3',6'-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-cboxylic acid 3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-6-cboxylic acid 6-FAM Acid 6-Cboxyfluoroscein 6-FAM, 6-CF Spiro[phthalan-1,9′-xanthene]-6-cboxylic Acid, 3′,6′-dihydroxy-3-oxo 6-FAM 6-FAM Hydrate 6-Cboxyfluorescein Hydrate> 2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)-terht 6-Cboxyfluoroscein SynonyMs 3',6'-Dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-6-cboxylic acid 2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-TERHTHALIC ACID 6-Cboxyfluorescein,6-FAM, FLUOS 6-Cboxyfluorescein, Single isomer 6-Cboxyfluorescein (6-FAM) Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-cboxylicacid, 3',6'-dihydroxy-3-oxo 6-FAM, 2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)-terhthalic acid 6-FAM een) 6-FAM (6-Cboxyfluorescein), Amine-reactive fluorescent label 3',6'-dihydroxy-1-oxo-spiro[2-benzofuran-3,9'-xanthene]-5-cboxylic acid 3',6'-dihydroxy-1-keto-spiro[isobenzofuran-3,9'-xanthene]-5-cboxylic acid 3-9 6-Cboxyfluorescein 6-Cboxyfluorescein Hydrate 2-(3-hydroxy-6-oxo-6H-xanthen-9-yl)terhthalic acid 3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-6-cboxylic acid 3-Oxo-3',6'-dihydroxy-1,3-dihydrospiro[isobenzofuran-1,9'-[9H]xanthene]-6-cboxylic acid Carboxyfluorescein 6-FAM, 10 mM in DMSO 6-FAM,6-CF EINECS 276-331-1 6-FAM,FLUOS 3',6'-dihydroxy-1-oxospiro[2-benzofuran-3,9'-xanthene]-5-cboxylic acid |
| Description | The single isomer, 6-FAM, contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. In addition to its relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility, fluorescein has an excitation maximum that closely matches the 488 nm spectral line of the argon-ion laser. |
|---|---|
| Related Catalog |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 736.4±60.0 °C at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C21H12O7 |
| Molecular Weight | 376.316 |
| Flash Point | 271.0±26.4 °C |
| Exact Mass | 376.058289 |
| PSA | 113.29000 |
| LogP | 2.66 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.816 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2915900090 |
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3301-79-9 |
| Literature: Russian Journal of General Chemistry, , vol. 65, # 3.2 p. 454 - 456 Zhurnal Obshchei Khimii, , vol. 65, # 3 p. 511 - 513 |
| Precursor 2 | |
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| DownStream 1 | |
| HS Code | 2915900090 |
|---|---|
| Summary | 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0% |