6-Carboxyfluorescein
6-Carboxyfluorescein structure
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Common Name | 6-Carboxyfluorescein | ||
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| CAS Number | 3301-79-9 | Molecular Weight | 376.316 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 736.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C21H12O7 | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 271.0±26.4 °C | |
Use of 6-CarboxyfluoresceinThe single isomer, 6-FAM, contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. In addition to its relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility, fluorescein has an excitation maximum that closely matches the 488 nm spectral line of the argon-ion laser. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-carboxyfluorescein |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | The single isomer, 6-FAM, contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. In addition to its relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility, fluorescein has an excitation maximum that closely matches the 488 nm spectral line of the argon-ion laser. |
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| Related Catalog |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 736.4±60.0 °C at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C21H12O7 |
| Molecular Weight | 376.316 |
| Flash Point | 271.0±26.4 °C |
| Exact Mass | 376.058289 |
| PSA | 113.29000 |
| LogP | 2.66 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.816 |
| InChIKey | BZTDTCNHAFUJOG-UHFFFAOYSA-N |
| SMILES | O=C(O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2915900090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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6-Carboxyfluorescein CAS#:3301-79-9
Learn More
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| Literature: Russian Journal of General Chemistry, , vol. 65, # 3.2 p. 454 - 456 Zhurnal Obshchei Khimii, , vol. 65, # 3 p. 511 - 513 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 1 | |
CAS#:92557-81-8This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2915900090 |
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| Summary | 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity.
Oncotarget 5(18) , 8107-22, (2014) p53 plays a key role in regulating DNA damage response by suppressing cell cycle progression or inducing apoptosis depending on extent of DNA damage. However, it is not clear why mild genotoxic stress... |
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Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response.
Infect. Immun. 83(2) , 591-603, (2015) The complement system is a key component of the host immune response for the recognition and clearance of Streptococcus pneumoniae. In this study, we demonstrate that the amidase LytA, the main pneumo... |
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Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.
Exp. Cell Res. 338 , 251-60, (2015) Cellular levels of inhibitor of apoptosis (IAP) proteins are elevated in multiple human cancers and their activities often play a part in promoting cancer cell survival by blocking apoptotic pathways,... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Cellular uptake in human CCRF-CEM cells at 10 uM after 1 hr by real time fluorescence...
Source: ChEMBL
Target: CCRF-CEM
External Id: CHEMBL1764633
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 6-carboxy-fluorescein |
| 6-Carboxyfluorescein |
| 3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid |
| 6-FAM |
| 6-FAM Hydrate |
| Carboxyfluorescein |
| MFCD00036873 |
| 6-FAM,6-CF |
| 6-FAM FLUOS |
| EINECS 276-331-1 |
| 6-FAM,FLUOS |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the safety information for 6-carboxyfluorescein? |
| A: Safety information for 6-carboxyfluorescein: S26-S36/37. |
| Q: What is the InChIKey of 6-carboxyfluorescein? |
| A: InChIKey of 6-carboxyfluorescein is BZTDTCNHAFUJOG-UHFFFAOYSA-N. |
| Q: How is the water solubility of 6-carboxyfluorescein? |
| A: Water solubility of 6-carboxyfluorescein: DMSO: soluble. |
| Q: What is the English name of 6-carboxyfluorescein? |
| A: The English name of 6-carboxyfluorescein is 6-carboxyfluorescein. |
| Q: What is the melting point of 6-carboxyfluorescein? |
| A: Melting point of 6-carboxyfluorescein is >300 °C(lit.). |
| Q: What is the polar surface area (PSA) of 6-carboxyfluorescein? |
| A: Polar surface area (PSA) of 6-carboxyfluorescein is 113.29000. |
| Q: What are the upstream materials of 6-carboxyfluorescein? |
| A: Related upstream materials(CAS) of 6-carboxyfluorescein: 108-46-3;552-30-7. |
| Q: What English synonyms does 6-carboxyfluorescein have? |
| A: English synonyms of 6-carboxyfluorescein: 6-carboxy-fluorescein, 6-Carboxyfluorescein, 3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid, 6-FAM, 6-FAM Hydrate, Carboxyfluorescein, MFCD00036873, 6-FAM,6-CF, 6-FAM FLUOS, EINECS 276-331-1, 6-FAM,FLUOS. |
| Q: What is the SMILES notation of 6-carboxyfluorescein? |
| A: SMILES notation of 6-carboxyfluorescein is O=C(O)c1ccc2c(c1)C1(OC2=O)c2ccc(O)cc2Oc2cc(O)ccc21. |
| Q: What is the molecular weight of 6-carboxyfluorescein? |
| A: Molecular weight of 6-carboxyfluorescein is 376.316. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |